Skip to content

D68.61

Billable

Antiphospholipid syndrome

HCC Category Mapping

V24HCC 48Coagulation Defects and Other Specified Hematological Disorders
0.209
ESRDHCC 48Coagulation Defects and Other Specified Hematological Disorders
0.000

What This Code Means

An autoimmune condition where the body produces antibodies that interfere with blood clotting, causing either excessive bleeding or clotting.

Coding Tips

  • Document positive antiphospholipid antibody test results (anticardiolipin, anti-beta-2 glycoprotein, lupus anticoagulant)
  • Link to associated thrombotic or hemorrhagic events; this condition often coexists with lupus (SLE)

Clinical Significance

Antiphospholipid syndrome is an acquired systemic autoimmune thrombophilia characterized by vascular thrombosis (arterial or venous) and/or pregnancy morbidity in the presence of persistent antiphospholipid antibodies. It may be primary or secondary to systemic lupus erythematosus. Catastrophic antiphospholipid syndrome, involving multi-organ thrombosis, carries high mortality.

Documentation Requirements

  • Document positive antiphospholipid antibodies on two occasions at least 12 weeks apart (anticardiolipin IgG/IgM, anti-beta2 glycoprotein I IgG/IgM, or lupus anticoagulant), clinical criteria met (vascular thrombosis or pregnancy morbidity), and whether the condition is primary or secondary.
  • Record current anticoagulation regimen and target INR.

Excludes 1 — Do NOT code together

  • anti-phospholipid antibody, finding without diagnosis (R76.0)

Excludes 2 — Not included here, may code separately

  • anti-phospholipid antibody with hemorrhagic disorder (D68.312)
  • lupus anticoagulant syndrome (D68.62)

Commonly Confused Codes

Code Hierarchy

Open D68.61 in the Interactive Encoder

See full code details, AI coding tips, HCC mappings, and related codes in our interactive encoder. Start your 14-day Pro trial — no credit card required.