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D68.312 ICD-10-CM Code: Antiphospholipid antibody with hemorrhagic disorder

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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)

D68.312

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Antiphospholipid antibody with hemorrhagic disorder

A bleeding disorder caused by antiphospholipid antibodies that interfere with blood clotting and increase bleeding risk.

Buddy the Bee presenting code insight

Buddy Insight

Antiphospholipid antibody with hemorrhagic disorder represents the uncommon scenario where antiphospholipid antibodies cause bleeding rather than the more typical thrombotic presentation.

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

HCC 48

RAF 0.209

ACA/HHS

0

0

RAF 0

ESRD/PACE

HCC 48

RAF 0.0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
D68.3Hemorrhagic disorder due to circulating anticoagulants
D68.31Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.312Antiphospholipid antibody with hemorrhagic disorder

Inclusion Terms

Official
  • Lupus anticoagulant (LAC) with hemorrhagic disorder
  • Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder

Excludes 2

Official
  • antiphospholipid antibody syndrome (D68.61)
  • antiphospholipid antibody with hypercoagulable state (D68.61)
  • lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
  • systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)

Related Child Codes

Official
D68.311Acquired hemophilia
D68.318Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors

Includes

Official

ICD-10-CM does not list Includes notes for D68.312 in this effective period.

Excludes 1

Official
  • antiphospholipid antibody, finding without diagnosis (R76.0)
  • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
  • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D68.312 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D68.312 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for D68.312 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance
Document positive antiphospholipid antibodies (anticardiolipin, anti-beta2 glycoprotein I, lupus anticoagulant), specific hemorrhagic manifestations, prothrombin levels if hypoprothrombinemia is suspected, and platelet count.
Record the underlying condition if secondary (systemic lupus erythematosus, other autoimmune disease) and treatment approach.

MEAT Support

HCC Buddy guidance
Document positive antiphospholipid antibodies (anticardiolipin, anti-beta2 glycoprotein I, lupus anticoagulant), specific hemorrhagic manifestations, prothrombin levels if hypoprothrombinemia is suspected, and platelet count.
Record the underlying condition if secondary (systemic lupus erythematosus, other autoimmune disease) and treatment approach.

Audit Caution

HCC Buddy guidance
This code is specifically for hemorrhagic manifestations of antiphospholipid antibodies — do not use for the typical thrombotic antiphospholipid syndrome (D68.61).
The term 'anticoagulant' in lupus anticoagulant is a laboratory misnomer — these patients usually clot rather than bleed.
Only use D68.312 when true clinical bleeding is present.

Common Mistakes

HCC Buddy guidance
D68.61 (Antiphospholipid syndrome) — thrombotic presentation is far more common
D68.62 (Lupus anticoagulant syndrome) — typically prothrombotic despite the misleading name
D68.311 (Acquired hemophilia) — different autoantibody target (factor VIII vs. phospholipid-binding proteins).

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is D68.312 an HCC code?

Yes. D68.312 maps to Coagulation Defects and Other Specified Hematological Disorders under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 48, Coagulation Defects and Other Specified Hematological Disorders
0.209
ESRDHCC 48, Coagulation Defects and Other Specified Hematological Disorders
0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work D68.312 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for D68.312

For D68.312to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed D68.312 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

D68.312 is the ICD-10-CM diagnosis code for antiphospholipid antibody with hemorrhagic disorder. A bleeding disorder caused by antiphospholipid antibodies that interfere with blood clotting and increase bleeding risk. D68.312 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering coagulation defects, purpura and other hemorrhagic conditions (d65-d69).

Under the older CMS-HCC V24 model, D68.312 maps to Coagulation Defects and Other Specified Hematological Disorders (HCC 48) with a community, non-dual, aged base RAF weight of 0.209. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Document the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin, or anti-beta-2 glycoprotein) confirmed by testing. Because D68.312 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D68.312 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • Document the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin, or anti-beta-2 glycoprotein) confirmed by testing
  • Distinguish between thrombotic and hemorrhagic presentations; this code is specifically for hemorrhagic manifestations

Clinical Significance

Antiphospholipid antibody with hemorrhagic disorder represents the uncommon scenario where antiphospholipid antibodies cause bleeding rather than the more typical thrombotic presentation. This may occur when antiphospholipid antibodies bind to prothrombin causing hypoprothrombinemia, or when severe thrombocytopenia develops. The hemorrhagic presentation requires different management than typical antiphospholipid syndrome.

Documentation Requirements

  • Document positive antiphospholipid antibodies (anticardiolipin, anti-beta2 glycoprotein I, lupus anticoagulant), specific hemorrhagic manifestations, prothrombin levels if hypoprothrombinemia is suspected, and platelet count.
  • Record the underlying condition if secondary (systemic lupus erythematosus, other autoimmune disease) and treatment approach.

Excludes 1, Do NOT code together

  • antiphospholipid antibody, finding without diagnosis (R76.0)
  • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
  • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)

Excludes 2, Not included here, may code separately

  • antiphospholipid antibody syndrome (D68.61)
  • antiphospholipid antibody with hypercoagulable state (D68.61)
  • lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
  • systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)

Commonly Confused Codes

  • D68.61 (Antiphospholipid syndrome): thrombotic presentation is far more common
  • D68.62 (Lupus anticoagulant syndrome): typically prothrombotic despite the misleading name
  • D68.311 (Acquired hemophilia): different autoantibody target (factor VIII vs. phospholipid-binding proteins).

Child Codes

Code Hierarchy

Because D68.312 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

Work D68.312 in HCC Buddy

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