R65.11

Billable

Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

HCC Category Mapping

V28HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

0.455

V24HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

0.455

ESRDHCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

0.000

What This Code Means

A systemic inflammatory response in the body caused by non-infectious triggers that has progressed to cause failure of one or more organs.

Coding Tips

•Document which organ systems are affected (respiratory, renal, cardiovascular, etc.) for complete clinical picture
•Confirm non-infectious etiology and code the underlying cause (trauma, pancreatitis, transfusion reaction)

Clinical Significance

SIRS with acute organ dysfunction represents progression to a more severe systemic inflammatory state requiring intensive care and aggressive intervention. The presence of organ dysfunction significantly increases mortality risk and indicates need for organ support therapies.

Documentation Requirements

✓Documentation of SIRS criteria (temperature, heart rate, respiratory rate, WBC)
✓Non-infectious underlying cause
✓Evidence of acute organ dysfunction (renal, hepatic, cardiac, pulmonary)
✓Laboratory markers of organ failure
✓ICU level of care
✓Organ support interventions (ventilation, dialysis, vasopressors)
✓Serial organ function monitoring
✓Response to treatment documentation

Use Additional Code

code to identify specific acute organ dysfunction, such as:
acute kidney failure (N17.-)
acute respiratory failure (J96.0-)
critical illness myopathy (G72.81)
critical illness polyneuropathy (G62.81)
disseminated intravascular coagulopathy [DIC] (D65)
encephalopathy (metabolic) (septic) (G93.41)
hepatic failure (K72.0-)

Commonly Confused Codes

R65.10 — SIRS without organ dysfunction (less severe presentation)R65.21 — Severe sepsis with septic shock (infectious cause with shock)R65.20 — Severe sepsis without septic shock (infectious cause)R57.9 — Shock, unspecified (hemodynamic compromise primary)

Code Hierarchy

└R65Symptoms and signs specifically associated with systemic inflammation and infection └R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious origin └R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

└R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction