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G92.02 ICD-10-CM Code: Immune effector cell-associated neurotoxicity syndrome, grade 2

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FY 2026 Apr update / Diseases of the nervous system (G00-G99) / Other disorders of the nervous system (G89-G99)

G92.02

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Immune effector cell-associated neurotoxicity syndrome, grade 2

A moderate neurological side effect from immunotherapy treatment causing noticeable symptoms that may interfere with daily activities.

CMS-HCC V28

N/A

—

Not mapped

CMS-HCC V24

N/A

—

Not mapped

ACA/HHS

N/A

—

Not mapped

ESRD/PACE

N/A

—

Not mapped

RXHCC

N/A

—

Not mapped

Code Book Path

Official
G92Toxic encephalopathy
G92.0Immune effector cell-associated neurotoxicity syndrome
G92.02Immune effector cell-associated neurotoxicity syndrome, grade 2

Inclusion Terms

Official
  • ICANS, grade 2

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for G92.02 in this effective period.

Related Child Codes

Official
G92.00Immune effector cell-associated neurotoxicity syndrome, grade unspecified
G92.01Immune effector cell-associated neurotoxicity syndrome, grade 1
G92.03Immune effector cell-associated neurotoxicity syndrome, grade 3
G92.04Immune effector cell-associated neurotoxicity syndrome, grade 4
G92.05Immune effector cell-associated neurotoxicity syndrome, grade 5

Includes

Official

ICD-10-CM does not list Includes notes for G92.02 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for G92.02 in this effective period.

Code First

Official
  • underlying cause such as:
  • complications of immune effector cellular therapy (T80.82)

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for G92.02 in this effective period.

Code Also

Official
  • , if applicable, associated signs and symptoms, such as:
  • cerebral edema (G93.6)
  • unspecified convulsions (R56.9)

Buddy Documentation Tip

HCC Buddy guidance
Verify Grade 2 severity is explicitly documented; refer to institutional grading criteria if needed
Document any interventions or treatments provided for symptom management

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is G92.02 an HCC code?

No. G92.02 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.

Code
G92.02
Description
Immune effector cell-associated neurotoxicity syndrome, grade 2
HCC (V28)
No CMS-HCC V28 mapping
RAF
—
Billable
Yes
Payment year
2026

Coder workflow notes

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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

G92.02 is the ICD-10-CM diagnosis code for immune effector cell-associated neurotoxicity syndrome, grade 2. A moderate neurological side effect from immunotherapy treatment causing noticeable symptoms that may interfere with daily activities. G92.02 sits in the ICD-10-CM chapter for diseases of the nervous system (g00-g99), within the section covering other disorders of the nervous system (g89-g99).

G92.02 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

Verify Grade 2 severity is explicitly documented; refer to institutional grading criteria if needed.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for G92.02 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • •Verify Grade 2 severity is explicitly documented; refer to institutional grading criteria if needed
  • •Document any interventions or treatments provided for symptom management

Child Codes

G92.00Immune effector cell-associated neurotoxicity syndrome, grade unspecified
G92.01Immune effector cell-associated neurotoxicity syndrome, grade 1
G92.02Immune effector cell-associated neurotoxicity syndrome, grade 2
G92.03Immune effector cell-associated neurotoxicity syndrome, grade 3
G92.04Immune effector cell-associated neurotoxicity syndrome, grade 4
G92.05Immune effector cell-associated neurotoxicity syndrome, grade 5

Code Hierarchy

└G92Toxic encephalopathy└G92.0Immune effector cell-associated neurotoxicity syndrome└G92.02Immune effector cell-associated neurotoxicity syndrome, grade 2
└G92.02Immune effector cell-associated neurotoxicity syndrome, grade 2

G92.02 code history

Code setChange
FY2022 (effective Oct 1, 2021)Added to the code set

Source: official CMS ICD-10-CM order and addenda files, FY2016 through FY2027.

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