E75.6 ICD-10-CM Code: Lipid storage disorder, unspecified
E75.6 is not a CMS-HCC payment code. MEAT criteria · RAF calculator · HCC coding software
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E75.6
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceLipid storage disorder, unspecified
A general category for inherited metabolic disorders involving abnormal accumulation of fatty substances when the specific type cannot be identified.
Buddy Insight
Lipid storage disorder, unspecified is used when a provider has confirmed a lipid storage disorder but the specific type has not been identified or documented.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
MappedHCC 43
RAF 0.063
Code Book Path
Inclusion Terms
OfficialICD-10-CM does not list inclusion terms for E75.6 in this effective period.
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E75.6 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E75.6 in this effective period.
Excludes 1
Official- mucolipidosis, types I-III (E77.0-E77.1)
- Refsum's disease (G60.1)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E75.6 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E75.6 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E75.6 in this effective period.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E75.6 an HCC code?
E75.6 is not in the CMS-HCC V28 or V24 community payment model, but it does map to Other Significant Endocrine and Metabolic Disorders under the Part D RxHCC model.
- Code
- E75.6
- Description
- Lipid storage disorder, unspecified
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF
- —
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
Work E75.6 in the Code Book — tabular path, V28 RAF, and MEAT checklist →
MEAT Criteria for E75.6
For E75.6 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E75.6 during that encounter, not just copy-forwarded from a problem list.
Coder workflow notes
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What This Code Means
E75.6 is the ICD-10-CM diagnosis code for lipid storage disorder, unspecified. A general category for inherited metabolic disorders involving abnormal accumulation of fatty substances when the specific type cannot be identified. E75.6 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
E75.6 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
This code does not map to a CMS-HCC V28 payment category. Capture depends on documentation that supports the diagnosis; verify the HCC assignment against the current CMS mapping for the applicable payment year. Coders reviewing E75.6 should check whether additional documentation would support a more specific child code in the same hierarchy that does map to a payment HCC, capturing the correct specificity is the highest-impact RAF improvement available within accurate coding.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E75.6 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This is the least specific lipid storage disorder code; use only when no other E75 code applies
- •Query provider for additional diagnostic information to assign a more specific code
Clinical Significance
Lipid storage disorder, unspecified is used when a provider has confirmed a lipid storage disorder but the specific type has not been identified or documented. This nonspecific code signals that further diagnostic workup may be needed to identify the exact lysosomal storage disease for appropriate treatment planning.
Documentation Requirements
- ✓Provider statement confirming a lipid storage disorder diagnosis
- ✓Clinical findings suggestive of lipid accumulation (hepatosplenomegaly, neurological decline, biopsy findings)
- ✓Diagnostic workup performed or planned (enzyme studies, genetic panels)
- ✓Reason the specific type is unknown (pending results, inconclusive testing, atypical presentation)
- ✓Current symptoms and management plan
Commonly Confused Codes
- •E75.5: Other lipid storage disorders: use when the type is known but does not have a specific code
- •E75.3: Sphingolipidosis, unspecified: more specific than E75.6 if sphingolipid involvement is confirmed
- •E78.9: Disorder of lipoprotein metabolism, unspecified: for circulating lipid abnormalities, NOT intracellular storage
- •E88.9: Metabolic disorder, unspecified: too broad; use E75.6 when lipid storage is confirmed