What is ICD-10 code E72.59?

E72.59 is the ICD-10-CM diagnosis code for Other disorders of glycine metabolism. Other rare metabolic disorders affecting how the body processes glycine, an amino acid important for protein synthesis and nervous system function. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E72.59 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E72.59 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E72.59 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E72.59 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for E72.59?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. E72.59 was a payment HCC under V24 (Other Significant Endocrine and Metabolic Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting E72.59?

Document the specific glycine metabolism disorder identified in the medical record Ensure this code is used only when the disorder does not fit into more specific glycine metabolism codes Because E72.59 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

E72.59: Other disorders of glycine metabolism —

ICD-10-CM Code View

HCC Buddy Code Card

Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.

Code lookupE72.59Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E72.59

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other disorders of glycine metabolism

Other rare metabolic disorders affecting how the body processes glycine, an amino acid important for protein synthesis and nervous system function.

Buddy Insight

CMS-HCC V28

Not risk-adjusted for this model/period.

RAF 0

CMS-HCC V24

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.230

ACA/HHS

Not risk-adjusted for this model/period.

RAF 0

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.0

RXHCC

Mapped

HCC 43

Other Significant Endocrine a...

RAF 0.0

Code Trumping

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Code Book Path

Official

E72Other disorders of amino-acid metabolism

E72.5Disorders of glycine metabolism

E72.59Other disorders of glycine metabolism

Inclusion Terms

Official

D-glycericacidemia
Hyperhydroxyprolinemia
Hyperprolinemia (types I, II)
Sarcosinemia

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E72.59 in this effective period.

Related Child Codes

Official

E72.50Disorder of glycine metabolism, unspecified

E72.51Non-ketotic hyperglycinemia

E72.52Trimethylaminuria

E72.53Primary hyperoxaluria

E72.54Secondary hyperoxaluria

Includes

Official

ICD-10-CM does not list Includes notes for E72.59 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for E72.59 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E72.59 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E72.59 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E72.59 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Specific glycine metabolism disorder named in the documentation

Biochemical or genetic testing confirming the specific diagnosis

Clinical manifestations and organ involvement documented

Current treatment plan and monitoring schedule

MEAT Support

HCC Buddy guidance

Specific glycine metabolism disorder named in the documentation

Biochemical or genetic testing confirming the specific diagnosis

Clinical manifestations and organ involvement documented

Current treatment plan and monitoring schedule

Audit Caution

HCC Buddy guidance

Using this code when non-ketotic hyperglycinemia or trimethylaminuria has been documented — those have specific codes

Defaulting to the unspecified code (E72.50) when the specific glycine disorder is named in the documentation

Confusing primary hyperoxaluria (a glycine/glyoxylate pathway disorder) with secondary hyperoxaluria from dietary causes

Not recognizing that some conditions coded here may have complications requiring separate coding

Common Mistakes

HCC Buddy guidance

E72.50 — Disorder of glycine metabolism, unspecified: use only when no specific glycine disorder is identified

E72.51 — Non-ketotic hyperglycinemia: a specific glycine cleavage system defect with its own code

E72.52 — Trimethylaminuria: has its own specific code

E72.89 — Other specified disorders of amino-acid metabolism: broader category for non-glycine amino acid disorders

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is E72.59 an HCC code?

Yes. E72.59 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 23, Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 43, Other Significant Endocrine and Metabolic Disorders

0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

MEAT Criteria for E72.59

For E72.59to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E72.59 during that encounter, not just copy-forwarded from a problem list.

What This Code Means

E72.59 is the ICD-10-CM diagnosis code for other disorders of glycine metabolism. Other rare metabolic disorders affecting how the body processes glycine, an amino acid important for protein synthesis and nervous system function. E72.59 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Under the older CMS-HCC V24 model, E72.59 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.230. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Document the specific glycine metabolism disorder identified in the medical record. Because E72.59 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E72.59 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Document the specific glycine metabolism disorder identified in the medical record
•Ensure this code is used only when the disorder does not fit into more specific glycine metabolism codes

Clinical Significance

Other disorders of glycine metabolism captures specified glycine metabolism disorders that do not have their own unique ICD-10 code, such as sarcosinemia, hyperoxaluria type I (primary), or D-glyceric aciduria. These rare conditions can cause kidney stones, neurological symptoms, or other organ damage. Proper identification supports resource allocation for the specialized management these patients require.

Documentation Requirements

✓Specific glycine metabolism disorder named in the documentation
✓Biochemical or genetic testing confirming the specific diagnosis
✓Clinical manifestations and organ involvement documented
✓Current treatment plan and monitoring schedule
✓Rationale for why the disorder does not fit a more specific code (E72.51 or E72.52)

Commonly Confused Codes

•E72.50: Disorder of glycine metabolism, unspecified: use only when no specific glycine disorder is identified
•E72.51: Non-ketotic hyperglycinemia: a specific glycine cleavage system defect with its own code
•E72.52: Trimethylaminuria: has its own specific code
•E72.89: Other specified disorders of amino-acid metabolism: broader category for non-glycine amino acid disorders