What is ICD-10 code E70.29?

E70.29 is the ICD-10-CM diagnosis code for Other disorders of tyrosine metabolism. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E70.29 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E70.29 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E70.29 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E70.29 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for E70.29?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. E70.29 was a payment HCC under V24 (Other Significant Endocrine and Metabolic Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting E70.29?

Use this code only after excluding more specific tyrosine metabolism disorders (E70.20-E70.28), such as phenylketonuria or alkaptonuria Ensure documentation specifies the particular tyrosine metabolism abnormality and consider requesting clarification from the provider if the specific disorder type is unclear Because E70.29 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

2026 ICD-10-CM E70.29: Other disorders of tyrosine

ICD-10-CM Code View

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Code lookupE70.29Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E70.29

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other disorders of tyrosine metabolism

This code describes metabolic disorders affecting how the body processes tyrosine, an amino acid important for making proteins and certain hormones. These are rare genetic or acquired conditions that don't fit into other specific tyrosine metabolism disorders.

Buddy Insight

Other disorders of tyrosine metabolism encompasses rare metabolic conditions affecting tyrosine processing that do not fit into the specific categories of tyrosinemia or unspecified disorders.

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.194

ACA/HHS

Mapped

HCC 28

HHS-HCC 28

Varies by metal level

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.036

RXHCC

Mapped

HCC 43

Other Significant Endocrine a...

RAF 0.063

Code Book Path

Official

E70Disorders of aromatic amino-acid metabolism

E70.2Disorders of tyrosine metabolism

E70.29Other disorders of tyrosine metabolism

Inclusion Terms

Official

Alkaptonuria
Ochronosis

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E70.29 in this effective period.

Related Child Codes

Official

E70.20Disorder of tyrosine metabolism, unspecified

E70.21Tyrosinemia

Includes

Official

ICD-10-CM does not list Includes notes for E70.29 in this effective period.

Excludes 1

Official

transitory tyrosinemia of newborn (P74.5)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E70.29 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E70.29 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E70.29 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Documentation should specify the exact disorder of tyrosine metabolism with supporting laboratory evidence such as urine organic acid analysis, enzyme activity assays, or genetic testing.

Clinical manifestations, affected organ systems, and current management should be detailed.

For alkaptonuria, document homogentisic acid levels and any musculoskeletal or cardiovascular complications.

MEAT Support

HCC Buddy guidance

Documentation should specify the exact disorder of tyrosine metabolism with supporting laboratory evidence such as urine organic acid analysis, enzyme activity assays, or genetic testing.

Clinical manifestations, affected organ systems, and current management should be detailed.

For alkaptonuria, document homogentisic acid levels and any musculoskeletal or cardiovascular complications.

Audit Caution

HCC Buddy guidance

Do not default to this code without documentation of a specific tyrosine metabolism disorder that does not fit into other categories.

Ensure the provider clearly identifies the metabolic pathway affected.

Alkaptonuria-related arthropathy should be coded with both E70.29 and the appropriate arthropathy code.

Do not confuse tyrosine metabolism disorders with phenylalanine disorders, though the pathways are related.

Common Mistakes

HCC Buddy guidance

E70.21 (Tyrosinemia) is for the specific tyrosinemia diagnosis.

E70.20 (Disorder of tyrosine metabolism, unspecified) should only be used when no specific disorder can be identified.

E70.30-E70.39 (Albinism codes) involve the melanin pathway downstream from tyrosine.

M15-M19 (Osteoarthritis codes) may be needed additionally for joint complications of alkaptonuria.

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E70.29 an HCC code?

Yes. E70.29 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.

Code: E70.29
Description: Other disorders of tyrosine metabolism
HCC (V28): No CMS-HCC V28 mapping
RAF: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

V24HCC 23, Other Significant Endocrine and Metabolic Disorders

0.194

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

0.036

RxHCCHCC 43, Other Significant Endocrine and Metabolic Disorders

0.063

Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work E70.29 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for E70.29

For E70.29 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E70.29 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

E70.29 is the ICD-10-CM diagnosis code for other disorders of tyrosine metabolism. This code describes metabolic disorders affecting how the body processes tyrosine, an amino acid important for making proteins and certain hormones. These are rare genetic or acquired conditions that don't fit into other specific tyrosine metabolism disorders. E70.29 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Under the older CMS-HCC V24 model, E70.29 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.194. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Use this code only after excluding more specific tyrosine metabolism disorders (E70.20-E70.28), such as phenylketonuria or alkaptonuria. Because E70.29 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E70.29 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Use this code only after excluding more specific tyrosine metabolism disorders (E70.20-E70.28), such as phenylketonuria or alkaptonuria
•Ensure documentation specifies the particular tyrosine metabolism abnormality and consider requesting clarification from the provider if the specific disorder type is unclear

Clinical Significance

Other disorders of tyrosine metabolism encompasses rare metabolic conditions affecting tyrosine processing that do not fit into the specific categories of tyrosinemia or unspecified disorders. This includes conditions like alkaptonuria (ochronosis), which causes dark pigmentation of connective tissues and progressive arthropathy, and other variant metabolic defects in the tyrosine degradation pathway.

Documentation Requirements

✓Documentation should specify the exact disorder of tyrosine metabolism with supporting laboratory evidence such as urine organic acid analysis, enzyme activity assays, or genetic testing.
✓Clinical manifestations, affected organ systems, and current management should be detailed.
✓For alkaptonuria, document homogentisic acid levels and any musculoskeletal or cardiovascular complications.

Commonly Confused Codes

•E70.21 (Tyrosinemia) is for the specific tyrosinemia diagnosis.
•E70.20 (Disorder of tyrosine metabolism, unspecified) should only be used when no specific disorder can be identified.
•E70.30-E70.39 (Albinism codes) involve the melanin pathway downstream from tyrosine.
•M15-M19 (Osteoarthritis codes) may be needed additionally for joint complications of alkaptonuria.