E31.1 ICD-10-CM Code: Polyglandular hyperfunction
E31.1 maps to CMS-HCC V28 51. A source-labeled RAF reference is available. Documentation must support MEAT. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)
E31.1
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidancePolyglandular hyperfunction
A condition where multiple glands in the body produce excessive amounts of hormones, causing overactivity of the endocrine system.
Buddy Insight
Polyglandular hyperfunction involves simultaneous excessive hormone production from multiple endocrine glands.
CMS-HCC V28
MappedHCC 51
Code-level coefficient reference
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 030
Code-level coefficient reference
ESRD/PACE
MappedHCC 23
Code-level coefficient reference
RXHCC
MappedHCC 43
Code-level coefficient reference
Code Book Path
Inclusion Terms
OfficialICD-10-CM does not list inclusion terms for E31.1 in this effective period.
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E31.1 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E31.1 in this effective period.
Excludes 1
Official- multiple endocrine adenomatosis (E31.2-)
- multiple endocrine neoplasia (E31.2-)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E31.1 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E31.1 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E31.1 in this effective period.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E31.1 an HCC code?
Yes. E31.1 (Polyglandular hyperfunction) maps to HCC 51, Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.510. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: E31.1 is billable and maps to V28 HCC 51, Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- E31.1
- Description
- Polyglandular hyperfunction
- HCC (V28)
- HCC 51 — Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders
- RAF reference coefficient
- 0.510
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work E31.1 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT Criteria for E31.1
For E31.1 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E31.1 during that encounter, not just copy-forwarded from a problem list.
Coder workflow notes
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What This Code Means
E31.1 is the ICD-10-CM diagnosis code for polyglandular hyperfunction. A condition where multiple glands in the body produce excessive amounts of hormones, causing overactivity of the endocrine system. E31.1 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).
Under the CMS-HCC V28 risk adjustment model, E31.1 maps to Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders (HCC 51) with a source-labeled community, non-dual, aged reference coefficient of 0.510. No V24 mapping is shown for E31.1; use the applicable model and payment year when reviewing the V28 mapping. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Identify which specific glands are overactive to support clinical documentation and treatment planning. Because E31.1 maps to an HCC category, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) before the diagnosis is used for risk adjustment. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E31.1 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Identify which specific glands are overactive to support clinical documentation and treatment planning
- •This is rare; ensure documentation clearly supports polyglandular hyperfunction rather than single gland hyperfunction
Clinical Significance
Polyglandular hyperfunction involves simultaneous excessive hormone production from multiple endocrine glands. This rare condition can cause complex metabolic disturbances from the combined effects of multiple hormone excesses, requiring coordinated multidisciplinary endocrine management.
Documentation Requirements
- ✓Document which specific glands are overactive, individual hormone levels confirming excess production, underlying etiology (multiple adenomas, genetic syndrome, stimulatory antibodies), clinical manifestations from each overactive gland, and treatment approach for each component.