E31.1

Billable

Polyglandular hyperfunction

HCC Category Mapping

V28HCC 51 — Other Significant Endocrine and Metabolic Disorders

0.233

V24HCC 23 — Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 43 — Other Significant Endocrine and Metabolic Disorders

0.000

What This Code Means

A condition where multiple glands in the body produce excessive amounts of hormones, causing overactivity of the endocrine system.

Coding Tips

•Identify which specific glands are overactive to support clinical documentation and treatment planning
•This is rare; ensure documentation clearly supports polyglandular hyperfunction rather than single gland hyperfunction

Clinical Significance

Polyglandular hyperfunction involves simultaneous excessive hormone production from multiple endocrine glands. This rare condition can cause complex metabolic disturbances from the combined effects of multiple hormone excesses, requiring coordinated multidisciplinary endocrine management.

Documentation Requirements

✓Document which specific glands are overactive, individual hormone levels confirming excess production, underlying etiology (multiple adenomas, genetic syndrome, stimulatory antibodies), clinical manifestations from each overactive gland, and treatment approach for each component.

Excludes 1 — Do NOT code together

multiple endocrine adenomatosis (E31.2-)
multiple endocrine neoplasia (E31.2-)

Commonly Confused Codes

E31.0 (autoimmune polyglandular failure which is gland underactivity, not overactivity), E31.2x (multiple endocrine neoplasia which involves tumor formation), E22.x (single pituitary gland hyperfunction), E05.x (thyrotoxicosis as a single-gland hyperfunction).

Code Hierarchy

└E31Polyglandular dysfunction └E31.1Polyglandular hyperfunction

└E31.1Polyglandular hyperfunction