What is ICD-10 code E27.3?

E27.3 is the ICD-10-CM diagnosis code for Drug-induced adrenocortical insufficiency. Adrenal gland failure caused by medications, most commonly corticosteroids used to treat other conditions. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E27.3 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E27.3 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E27.3 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E27.3 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does E27.3 map to under V28?

E27.3 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for E27.3?

E27.3 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for E27.3?

E27.3 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

What documentation supports E27.3?

Always document the specific medication causing the insufficiency and code the drug interaction Consider if this is reversible upon medication discontinuation versus permanent damage E27.3 is not a CMS-HCC V28 payment code in the verified current source, so MEAT is not the payment hook. Documentation still has to support the diagnosis if you report it.

2026 ICD-10-CM E27.3: Drug-induced adrenocortical

E27.3 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC coding software

ICD-10-CM Code View

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Code lookupE27.3Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)

E27.3

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Drug-induced adrenocortical insufficiency

Adrenal gland failure caused by medications, most commonly corticosteroids used to treat other conditions.

Buddy Insight

Drug-induced adrenocortical insufficiency most commonly results from chronic exogenous glucocorticoid therapy that suppresses the hypothalamic-pituitary-adrenal axis, causing adrenal atrophy.

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

Mapped

HCC 030

HHS-HCC 030 adult, RAF varies...

Code-level coefficient reference

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

Code-level coefficient reference

RXHCC

Mapped

HCC 43

Pituitary, Adrenal Gland, and...

Code-level coefficient reference

Code Book Path

Official

E27Other disorders of adrenal gland

E27.3Drug-induced adrenocortical insufficiency

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E27.3 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E27.3 in this effective period.

Related Child Codes

Official

E27.0Other adrenocortical overactivity

E27.1Primary adrenocortical insufficiency

E27.2Addisonian crisis

E27.4Other and unspecified adrenocortical insufficiency

E27.5Adrenomedullary hyperfunction

Includes

Official

ICD-10-CM does not list Includes notes for E27.3 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for E27.3 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E27.3 in this effective period.

Use Additional

Official

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Code Also

Official

ICD-10-CM does not list Code Also instructions for E27.3 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Document the specific causative medication, duration of use, dose at time of insufficiency onset, cortisol and adrenocorticotropic hormone levels, adrenocorticotropic hormone stimulation test results, tapering plan, and whether the condition is expected to be reversible.

MEAT Support

HCC Buddy guidance

Audit Caution

HCC Buddy guidance

Always assign an additional adverse effect code for the causative drug.

This code represents the adrenal insufficiency from drug suppression, not the Cushing-like effects of active steroid use (E24.2).

Ensure documentation links the insufficiency to a specific medication.

Common Mistakes

HCC Buddy guidance

E27.1 (primary adrenocortical insufficiency from intrinsic adrenal disease), E27.2 (Addisonian crisis if acute decompensation occurs), E24.2 (drug-induced Cushing syndrome, the opposite scenario from steroid excess), E27.40 (unspecified adrenocortical insufficiency).

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E27.3 an HCC code?

E27.3 is not in the CMS-HCC V28 or V24 community payment model. E27.3 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E27.3 also appears in the HHS-HCC commercial risk model (HCC 030 (HHS-HCC 030 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.

Code: E27.3
Description: Drug-induced adrenocortical insufficiency
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

Not separately weighted

RxHCCHCC 43, Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work E27.3 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT Criteria for E27.3

For E27.3 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E27.3 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

E27.3 is the ICD-10-CM diagnosis code for drug-induced adrenocortical insufficiency. Adrenal gland failure caused by medications, most commonly corticosteroids used to treat other conditions. E27.3 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).

E27.3 has no mapping under the CMS-HCC V28 or V24 community payment models. E27.3 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E27.3 also appears in the HHS-HCC commercial risk model (HCC 030 (HHS-HCC 030 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

Always document the specific medication causing the insufficiency and code the drug interaction.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E27.3 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Always document the specific medication causing the insufficiency and code the drug interaction
•Consider if this is reversible upon medication discontinuation versus permanent damage

Clinical Significance

Drug-induced adrenocortical insufficiency most commonly results from chronic exogenous glucocorticoid therapy that suppresses the hypothalamic-pituitary-adrenal axis, causing adrenal atrophy. Upon abrupt discontinuation or dose reduction, patients lack the ability to mount an appropriate cortisol response to stress, risking adrenal crisis.

Documentation Requirements

✓Document the specific causative medication, duration of use, dose at time of insufficiency onset, cortisol and adrenocorticotropic hormone levels, adrenocorticotropic hormone stimulation test results, tapering plan, and whether the condition is expected to be reversible.

Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Commonly Confused Codes

•E27.1 (primary adrenocortical insufficiency from intrinsic adrenal disease), E27.2 (Addisonian crisis if acute decompensation occurs), E24.2 (drug-induced Cushing syndrome, the opposite scenario from steroid excess), E27.40 (unspecified adrenocortical insufficiency).