What is ICD-10 code E24.2?

E24.2 is the ICD-10-CM diagnosis code for Drug-induced Cushing's syndrome. Cushing's syndrome caused by taking certain medications (such as corticosteroids) that mimic or trigger the effects of excess cortisol in the body. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E24.2 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E24.2 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E24.2 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E24.2 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for E24.2?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. E24.2 was a payment HCC under V24 (Other Significant Endocrine and Metabolic Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting E24.2?

Always document the specific medication causing the condition in the medical record This is iatrogenic Cushing's syndrome; consider coding the medication as an external cause if applicable Because E24.2 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

2026 ICD-10-CM E24.2: Drug-induced Cushing's

ICD-10-CM Code View

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Code lookupE24.2Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)

E24.2

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Drug-induced Cushing's syndrome

Cushing's syndrome caused by taking certain medications (such as corticosteroids) that mimic or trigger the effects of excess cortisol in the body.

Buddy Insight

Drug-induced Cushing syndrome is the most common cause of Cushing syndrome overall, resulting from chronic exogenous corticosteroid use.

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.194

ACA/HHS

Mapped

HCC 30

HHS-HCC 30

Varies by metal level

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.036

RXHCC

Mapped

HCC 43

Other Significant Endocrine a...

RAF 0.063

Code Book Path

Official

E24Cushing's syndrome

E24.2Drug-induced Cushing's syndrome

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E24.2 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E24.2 in this effective period.

Related Child Codes

Official

E24.0Pituitary-dependent Cushing's disease

E24.1Nelson's syndrome

E24.3Ectopic ACTH syndrome

E24.4Alcohol-induced pseudo-Cushing's syndrome

E24.8Other Cushing's syndrome

Includes

Official

ICD-10-CM does not list Includes notes for E24.2 in this effective period.

Excludes 1

Official

congenital adrenal hyperplasia (E25.0)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E24.2 in this effective period.

Use Additional

Official

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Code Also

Official

ICD-10-CM does not list Code Also instructions for E24.2 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Document the specific causative medication (prednisone, dexamethasone, inhaled corticosteroids, topical steroids), duration and dose of use, clinical manifestations, cortisol levels, and plan for steroid tapering or management of cushingoid effects.

MEAT Support

HCC Buddy guidance

Audit Caution

HCC Buddy guidance

Always assign an additional adverse effect code (T38.0X5A/D/S for glucocorticoids) to identify the causative drug.

Do not confuse with endogenous Cushing syndrome.

This code specifically requires documentation that the syndrome is caused by medication use.

Common Mistakes

HCC Buddy guidance

E24.0 (pituitary-dependent Cushing disease from endogenous adrenocorticotropic hormone excess), E24.3 (ectopic adrenocorticotropic hormone syndrome), E24.9 (Cushing syndrome unspecified), E27.3 (drug-induced adrenocortical insufficiency which is the opposite effect).

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is E24.2 an HCC code?

Yes. E24.2 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.

Code: E24.2
Description: Drug-induced Cushing's syndrome
HCC (V28): No CMS-HCC V28 mapping
RAF: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

V24HCC 23, Other Significant Endocrine and Metabolic Disorders

0.194

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

0.036

RxHCCHCC 43, Other Significant Endocrine and Metabolic Disorders

0.063

Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work E24.2 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for E24.2

For E24.2to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E24.2 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

E24.2 is the ICD-10-CM diagnosis code for drug-induced cushing's syndrome. Cushing's syndrome caused by taking certain medications (such as corticosteroids) that mimic or trigger the effects of excess cortisol in the body. E24.2 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).

Under the older CMS-HCC V24 model, E24.2 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.194. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Always document the specific medication causing the condition in the medical record. Because E24.2 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E24.2 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Always document the specific medication causing the condition in the medical record
•This is iatrogenic Cushing's syndrome; consider coding the medication as an external cause if applicable

Clinical Significance

Drug-induced Cushing syndrome is the most common cause of Cushing syndrome overall, resulting from chronic exogenous corticosteroid use. It produces the full spectrum of cushingoid features including central obesity, moon facies, striae, glucose intolerance, and immunosuppression, with risk of adrenal crisis upon abrupt discontinuation.

Documentation Requirements

✓Document the specific causative medication (prednisone, dexamethasone, inhaled corticosteroids, topical steroids), duration and dose of use, clinical manifestations, cortisol levels, and plan for steroid tapering or management of cushingoid effects.

Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Commonly Confused Codes

•E24.0 (pituitary-dependent Cushing disease from endogenous adrenocorticotropic hormone excess), E24.3 (ectopic adrenocorticotropic hormone syndrome), E24.9 (Cushing syndrome unspecified), E27.3 (drug-induced adrenocortical insufficiency which is the opposite effect).