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D89.834

Billable

Cytokine release syndrome, grade 4

This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

A severe immune reaction with significant cytokine release causing serious systemic symptoms such as high fever, hypotension, and organ dysfunction, requiring intensive monitoring and treatment.

Coding Tips

  • •Grade 4 is life-threatening; document vital sign changes, organ involvement, and interventions required (vasopressors, ICU admission)
  • •Correlate with the triggering immunotherapy and document the timeline of symptom onset

Code Hierarchy

└D89Other disorders involving the immune mechanism, not elsewhere classified└D89.8Other specified disorders involving the immune mechanism, not elsewhere classified└D89.83Cytokine release syndrome└D89.834Cytokine release syndrome, grade 4
└D89.834Cytokine release syndrome, grade 4

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