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D89.831

Billable

Cytokine release syndrome, grade 1

This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

A mild immune reaction where the body releases excessive amounts of signaling proteins (cytokines) in response to treatment, typically occurring after CAR-T cell therapy or similar immunotherapies.

Coding Tips

  • •Always document the triggering event (CAR-T therapy, monoclonal antibody, etc.) in the medical record
  • •Grade 1 represents the mildest form; ensure the grade assignment matches clinical documentation of symptoms

Code Hierarchy

└D89Other disorders involving the immune mechanism, not elsewhere classified└D89.8Other specified disorders involving the immune mechanism, not elsewhere classified└D89.83Cytokine release syndrome└D89.831Cytokine release syndrome, grade 1
└D89.831Cytokine release syndrome, grade 1

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