D81.818
BillableOther biotin-dependent carboxylase deficiency
Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)
Is D81.818 an HCC code?
No. D81.818 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
D81.818 is the ICD-10-CM diagnosis code for other biotin-dependent carboxylase deficiency. A rare genetic disorder affecting enzymes that depend on biotin (a B vitamin) for proper function, other than biotinidase, causing immune and metabolic problems. D81.818 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).
D81.818 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Use this code only when a specific biotin-dependent carboxylase deficiency other than biotinidase is documented.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D81.818 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code only when a specific biotin-dependent carboxylase deficiency other than biotinidase is documented
- •Document the specific enzyme deficiency in the medical record for clarity and future reference