D81.810
BillableBiotinidase deficiency
Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)
Is D81.810 an HCC code?
No. D81.810 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
D81.810 is the ICD-10-CM diagnosis code for biotinidase deficiency. A rare genetic disorder where the body cannot properly break down biotin, a B vitamin, leading to immune system problems and metabolic issues. D81.810 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).
D81.810 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
This is a specific biotin-dependent enzyme deficiency; do not use D81.819 if biotinidase deficiency is specifically identified.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D81.810 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This is a specific biotin-dependent enzyme deficiency; do not use D81.819 if biotinidase deficiency is specifically identified
- •Often treatable with biotin supplementation; document response to treatment if applicable