D81.810 ICD-10-CM Code: Biotinidase deficiency
HCC Buddy Code Card
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Certain disorders involving the immune mechanism (D80-D89)
D81.810
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceBiotinidase deficiency
A rare genetic disorder where the body cannot properly break down biotin, a B vitamin, leading to immune system problems and metabolic issues.
CMS-HCC V28
00
RAF 0
CMS-HCC V24
00
RAF 0
ACA/HHS
00
RAF 0
ESRD/PACE
00
RAF 0
RXHCC
00
RAF 0
Code Trumping
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Code Book Path
Inclusion Terms
Official- Multiple carboxylase deficiency
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for D81.810 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for D81.810 in this effective period.
Excludes 1
Official- biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for D81.810 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for D81.810 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for D81.810 in this effective period.
Buddy Documentation Tip
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is D81.810 an HCC code?
No. D81.810 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
D81.810 is the ICD-10-CM diagnosis code for biotinidase deficiency. A rare genetic disorder where the body cannot properly break down biotin, a B vitamin, leading to immune system problems and metabolic issues. D81.810 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).
D81.810 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
This is a specific biotin-dependent enzyme deficiency; do not use D81.819 if biotinidase deficiency is specifically identified.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D81.810 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This is a specific biotin-dependent enzyme deficiency; do not use D81.819 if biotinidase deficiency is specifically identified
- •Often treatable with biotin supplementation; document response to treatment if applicable