D61.810

HCC Category Mapping

What This Code Means

A condition where chemotherapy drugs used to treat cancer cause a dangerous drop in all types of blood cells produced by the bone marrow.

Coding Tips

• •Always link this code to the underlying neoplasm code and the chemotherapy encounter code
• •Document the specific chemotherapy agent if available to support medical necessity

Clinical Significance

Antineoplastic chemotherapy induced pancytopenia is a common and expected complication of cancer chemotherapy where cytotoxic agents suppress all bone marrow cell lines, resulting in simultaneous anemia, neutropenia, and thrombocytopenia. The severity and duration of pancytopenia depend on the specific agents used, dose intensity, and patient factors including prior treatment, bone marrow reserve, and nutritional status. This condition represents a significant source of treatment morbidity including life-threatening infections, hemorrhage, and transfusion dependence.

Documentation Requirements

• ✓Document the specific chemotherapy regimen causing pancytopenia.
• ✓Record all three cytopenia values: hemoglobin, absolute neutrophil count, and platelet count.
• ✓Include the underlying malignancy being treated and the temporal relationship between chemotherapy administration and pancytopenia onset.
• ✓Document nadir blood counts and duration of pancytopenia.
• ✓Record supportive measures including growth factor support (granulocyte colony-stimulating factor), transfusions, infection prophylaxis, and any treatment delays or dose modifications resulting from pancytopenia.

Commonly Confused Codes