D49.81 ICD-10-CM Code: Neoplasm of unspecified behavior of retina and choroid
D49.81 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC coding software
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FY 2026 Apr update / Neoplasms (C00-D49) / Neoplasms of unspecified behavior (D49)
D49.81
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceNeoplasm of unspecified behavior of retina and choroid
This code describes an abnormal growth or tumor in the retina or choroid (the light-sensitive tissue at the back of the eye) where doctors cannot yet determine if it is cancer or benign. It is used when the behavior of the eye growth is uncertain and requires further investigation or monitoring.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Dark area on retina
- Retinal freckle
Excludes 2
Official- neoplasms of uncertain behavior (D37-D44, D48)Inherited from D49
Related Codes
Includes
Official- 'growth' NOSInherited from D49
- neoplasm NOSInherited from D49
- new growth NOSInherited from D49
- tumor NOSInherited from D49
Excludes 1
Official- neoplasm of unspecified behavior of eyelid (skin) (D49.2)Inherited from D49.8
- neoplasm of unspecified behavior of eyelid cartilage (D49.2)Inherited from D49.8
- neoplasm of unspecified behavior of great vessels (D49.2)Inherited from D49.8
- neoplasm of unspecified behavior of optic nerve (D49.7)Inherited from D49.8
Code First
OfficialNo Code First sequencing instructions are included in this display for D49.81. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for D49.81. Check the code and parent instructions in the Code Book.
Code Also
OfficialNo Code Also instructions are included in this display for D49.81. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is D49.81 an HCC code?
No. D49.81 is a billable ICD-10-CM code with no mapping under the current CMS-HCC V28 community payment model, and none under the ESRD, Part D RxHCC, or HHS-HCC models.
- Code
- D49.81
- Description
- Neoplasm of unspecified behavior of retina and choroid
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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What This Code Means
D49.81 is the ICD-10-CM diagnosis code for neoplasm of unspecified behavior of retina and choroid. This code describes an abnormal growth or tumor in the retina or choroid (the light-sensitive tissue at the back of the eye) where doctors cannot yet determine if it is cancer or benign. It is used when the behavior of the eye growth is uncertain and requires further investigation or monitoring. D49.81 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering neoplasms of unspecified behavior (d49).
D49.81 is a billable ICD-10-CM code, but no current CMS-HCC V28 community payment mapping is shown, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.
Use this code only when the pathology report or clinical documentation explicitly states 'unspecified behavior' or when the neoplasm cannot be classified as benign or malignant at the time of coding.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D49.81 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code only when the pathology report or clinical documentation explicitly states 'unspecified behavior' or when the neoplasm cannot be classified as benign or malignant at the time of coding
- •Once the behavior of the neoplasm is determined through biopsy or further testing, update the code to the appropriate malignant (C69.x) or benign (D31.x) code rather than keeping the unspecified behavior code

