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D49.8 ICD-10-CM Code: Neoplasm of unspecified behavior of other specified sites

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FY 2026 Apr update / Neoplasms (C00-D49) / Neoplasms of unspecified behavior (D49)

D49.8

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Neoplasm of unspecified behavior of other specified sites

Neoplasm of unspecified behavior of other specified sites

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
D49Neoplasms of unspecified behavior
D49.8Neoplasm of unspecified behavior of other specified sites

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for D49.8 in this effective period.

Excludes 2

Official
  • neoplasms of uncertain behavior (D37-D44, D48)

Related Child Codes

Official
D49.81Neoplasm of unspecified behavior of retina and choroid
D49.89Neoplasm of unspecified behavior of other specified sites

Includes

Official
  • 'growth' NOS
  • neoplasm NOS
  • new growth NOS
  • tumor NOS

Excludes 1

Official
  • neoplasm of unspecified behavior of eyelid (skin) (D49.2)
  • neoplasm of unspecified behavior of eyelid cartilage (D49.2)
  • neoplasm of unspecified behavior of great vessels (D49.2)
  • neoplasm of unspecified behavior of optic nerve (D49.7)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D49.8 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D49.8 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for D49.8 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Coder workflow notes

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What This Code Means

D49.8 is the ICD-10-CM diagnosis code for neoplasm of unspecified behavior of other specified sites. D49.8 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering neoplasms of unspecified behavior (d49).

Header codes like D49.8 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at D49.8's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D49.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Excludes 1, Do NOT code together

  • neoplasm of unspecified behavior of eyelid (skin) (D49.2)
  • neoplasm of unspecified behavior of eyelid cartilage (D49.2)
  • neoplasm of unspecified behavior of great vessels (D49.2)
  • neoplasm of unspecified behavior of optic nerve (D49.7)

Child Codes

Code Hierarchy

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