C92.62
BillableAcute myeloid leukemia with 11q23-abnormality in relapse
HCC Category Mapping
V28HCC 17 — Metastatic Cancer and Acute Leukemia
0.368V24HCC 8 — Metastatic Cancer and Acute Leukemia
2.484ESRDHCC 8 — Metastatic Cancer and Acute Leukemia
0.000RxHCCHCC 19 — Lymphoma and Other Cancers
0.000What This Code Means
A specific type of acute myeloid leukemia with a chromosomal abnormality (11q23) where the cancer has returned after a period of remission.
Coding Tips
- •Document both the cytogenetic abnormality and the relapse status in the medical record
- •Distinguish between initial presentation and relapse based on treatment history
Clinical Significance
Acute myeloid leukemia with 11q23-abnormality in relapse indicates recurrence of this cytogenetically defined AML subtype after prior remission. Relapsed AML with 11q23 rearrangements carries a poor prognosis, though outcomes vary by the specific fusion partner. Salvage therapy followed by allogeneic stem cell transplantation offers the best chance for long-term survival in eligible patients.
Documentation Requirements
- ✓Documentation must confirm prior remission and relapse with the 11q23/KMT2A rearrangement, ideally confirmed at relapse as clonal evolution may occur.
- ✓Duration of first remission, prior treatment regimens, and updated molecular/cytogenetic testing at relapse must be recorded.
- ✓Transplant candidacy assessment, donor search status, and salvage treatment plan should be documented.
Commonly Confused Codes
C92.60 (AML with 11q23 not in remission) is for primary refractory disease.C92.61 (AML with 11q23 in remission) is for controlled disease.C92.02 (AML in relapse) is less specific and does not capture the cytogenetic abnormality.C92.52 (AMML in relapse) may overlap clinically but does not specify the 11q23 abnormality.
Code Hierarchy
└C92Myeloid leukemia└C92.6Acute myeloid leukemia with 11q23-abnormality└C92.62Acute myeloid leukemia with 11q23-abnormality in relapse
└C92.62Acute myeloid leukemia with 11q23-abnormality in relapse