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ICD-10-CM Code View

HCC Buddy Code Card

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FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)

C91.90

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Lymphoid leukemia, unspecified not having achieved remission

A type of blood cancer affecting lymphoid cells that has not gone into remission or is actively progressing.

Buddy presenting code insight

Buddy Insight

Lymphoid leukemia, unspecified, not in remission is a nonspecific code used when the exact subtype of lymphoid leukemia cannot be determined but active disease is present.

CMS-HCC V28

HCC 22

RAF 0.0

CMS-HCC V24

HCC 10

RAF 0.675

ACA/HHS

0

0

RAF 0

ESRD/PACE

HCC 10

RAF 0.0

RXHCC

HCC 19

RAF 0.0

Code Trumping

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Code Book Path

Official
C91Lymphoid leukemia
C91.9Lymphoid leukemia, unspecified
C91.90Lymphoid leukemia, unspecified not having achieved remission

Inclusion Terms

Official
  • Lymphoid leukemia with failed remission
  • Lymphoid leukemia NOS

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for C91.90 in this effective period.

Related Child Codes

Official
C91.91Lymphoid leukemia, unspecified, in remission
C91.92Lymphoid leukemia, unspecified, in relapse

Includes

Official

ICD-10-CM does not list Includes notes for C91.90 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for C91.90 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for C91.90 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for C91.90 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for C91.90 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance
While this code is used for unspecified lymphoid leukemia, documentation efforts should aim to obtain the specific subtype through immunophenotyping, cytogenetics, and molecular studies.
The active disease status (not in remission) must be documented.
Any available diagnostic information, even if incomplete, should be recorded to support potential reclassification to a more specific code.

MEAT Support

HCC Buddy guidance
While this code is used for unspecified lymphoid leukemia, documentation efforts should aim to obtain the specific subtype through immunophenotyping, cytogenetics, and molecular studies.
The active disease status (not in remission) must be documented.
Any available diagnostic information, even if incomplete, should be recorded to support potential reclassification to a more specific code.

Audit Caution

HCC Buddy guidance
This code should be a last resort when subtype cannot be determined.
Query the provider before defaulting to this unspecified code, as most modern hematology workups can identify the specific subtype.
This code may be appropriate for initial encounters before complete diagnostic workup is available but should be updated once results return.
Using this code long-term may indicate incomplete diagnostic evaluation.

Common Mistakes

HCC Buddy guidance
More specific codes should always be used when available: C91.10 (B-CLL), C91.00 (ALL, not in remission), C91.30 (B-PLL), C91.40 (HCL), or other specified subtypes.
C91.Z0 (other lymphoid leukemia not in remission) is for specified types not classified elsewhere.
C95.90 (leukemia, unspecified) is even less specific and should not be used when the lymphoid lineage is confirmed.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is C91.90 an HCC code?

Yes. C91.90 maps to Colorectal, Bladder, and Other Cancers under the CMS-HCC V28 risk adjustment model (and Lymphoma and Other Cancers under V24).

HCC Category Mapping

V28HCC 22Colorectal, Bladder, and Other Cancers
0.000
V24HCC 10Lymphoma and Other Cancers
0.675
ESRDHCC 10Lymphoma and Other Cancers
0.000
RxHCCHCC 19Lymphoma and Other Cancers
0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

MEAT Criteria for C91.90

For C91.90to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically — it has to be re-documented and supported each calendar year.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed C91.90 during that encounter — not just copy-forwarded from a problem list.

What This Code Means

C91.90 is the ICD-10-CM diagnosis code for lymphoid leukemia, unspecified not having achieved remission. A type of blood cancer affecting lymphoid cells that has not gone into remission or is actively progressing. C91.90 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).

Under the CMS-HCC V28 risk adjustment model, C91.90 maps to Colorectal, Bladder, and Other Cancers (HCC 22) with a community, non-dual, aged base RAF weight of 0.000. Under the older CMS-HCC V24 model, C91.90 maps to Lymphoma and Other Cancers (HCC 10) with a community, non-dual, aged base RAF weight of 0.675. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Use this code when lymphoid leukemia is unspecified and the patient has not achieved remission status. Because C91.90 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C91.90 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • Use this code when lymphoid leukemia is unspecified and the patient has not achieved remission status
  • Verify documentation clearly states 'not in remission' or 'active disease' to distinguish from remission codes

Clinical Significance

Lymphoid leukemia, unspecified, not in remission is a nonspecific code used when the exact subtype of lymphoid leukemia cannot be determined but active disease is present. This code should be used sparingly and only when documentation lacks sufficient specificity to assign a more precise code. Unspecified codes may trigger medical record reviews and can indicate incomplete diagnostic workup.

Documentation Requirements

  • While this code is used for unspecified lymphoid leukemia, documentation efforts should aim to obtain the specific subtype through immunophenotyping, cytogenetics, and molecular studies.
  • The active disease status (not in remission) must be documented.
  • Any available diagnostic information, even if incomplete, should be recorded to support potential reclassification to a more specific code.

Commonly Confused Codes

  • More specific codes should always be used when available: C91.10 (B-CLL), C91.00 (ALL, not in remission), C91.30 (B-PLL), C91.40 (HCL), or other specified subtypes.
  • C91.Z0 (other lymphoid leukemia not in remission) is for specified types not classified elsewhere.
  • C95.90 (leukemia, unspecified) is even less specific and should not be used when the lymphoid lineage is confirmed.

Child Codes

Code Hierarchy

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