C84.10
BillableSézary disease, unspecified site
HCC Category Mapping
V28HCC 17 — Metastatic Cancer and Acute Leukemia
0.368V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 19 — Lymphoma and Other Cancers
0.000What This Code Means
Sézary disease, an aggressive form of skin cancer involving abnormal white blood cells, when the specific location of lymph node involvement is not specified.
Coding Tips
Clinical Significance
Sezary disease at an unspecified site is an aggressive leukemic variant of cutaneous T-cell lymphoma characterized by erythroderma (generalized skin redness affecting most of the body surface), lymphadenopathy, and circulating malignant T-cells (Sezary cells) in the peripheral blood. It is classified as Stage IVA or higher and carries a significantly worse prognosis than mycosis fungoides, with median survival of 2-4 years.
Documentation Requirements
- ✓Skin biopsy confirming cutaneous T-cell lymphoma
- ✓Peripheral blood flow cytometry or morphology demonstrating circulating Sezary cells (atypical T-cells with cerebriform nuclei)
- ✓Documentation of erythroderma with body surface area involvement
- ✓Lymph node assessment and staging documentation
- ✓Treatment plan — typically systemic therapy required
Commonly Confused Codes
C84.00 — Mycosis fungoides, unspecified site: Mycosis fungoides is primarily cutaneous without significant blood involvement; Sezary disease requires circulating malignant T-cellsC84.40 — Peripheral T-cell lymphoma, unspecified: Sezary disease is a specific form of T-cell lymphoma with defined diagnostic criteriaL53.9 — Erythematous condition, unspecified: Erythroderma from Sezary disease should be coded with the lymphoma code, not a dermatologic code
Code Hierarchy
└C84Mature T/NK-cell lymphomas└C84.1Sézary disease└C84.10Sézary disease, unspecified site
└C84.10Sézary disease, unspecified site