C81.48
BillableLymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)
Is C81.48 an HCC code?
Yes. C81.48 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors under the CMS-HCC V28 risk adjustment model (and Lymphoma and Other Cancers under V24).
HCC Category Mapping
RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
MEAT Criteria for C81.48
For C81.48 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically — it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed C81.48 during that encounter — not just copy-forwarded from a problem list.
What This Code Means
C81.48 is the ICD-10-CM diagnosis code for lymphocyte-rich hodgkin lymphoma, lymph nodes of multiple sites. This is a type of Hodgkin lymphoma (a cancer of the lymph system) where lymphocytes are the predominant cell type, and the cancer is present in lymph nodes at multiple locations throughout the body. It represents a less common subtype of Hodgkin lymphoma with a generally favorable prognosis. C81.48 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of lymphoid, hematopoietic and related tissue (c81-c96).
Under the CMS-HCC V28 risk adjustment model, C81.48 maps to Breast, Prostate, Colorectal and Other Cancers and Tumors (HCC 21) with a community, non-dual, aged base RAF weight of 0.545. Under the older CMS-HCC V24 model, C81.48 maps to Lymphoma and Other Cancers (HCC 10) with a community, non-dual, aged base RAF weight of 0.675. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.
The '48' extension indicates multiple lymph node sites are involved; ensure documentation specifies involvement of lymph nodes at different anatomical regions (e.g., cervical, axillary, mediastinal, abdominal) to justify this code rather than single-site codes (C81.41-C81.47). Because C81.48 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C81.48 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •The '48' extension indicates multiple lymph node sites are involved; ensure documentation specifies involvement of lymph nodes at different anatomical regions (e.g., cervical, axillary, mediastinal, abdominal) to justify this code rather than single-site codes (C81.41-C81.47)
- •This code requires confirmation of both the histological subtype (lymphocyte-rich) and the extent of disease; coordinate with pathology reports and staging documentation to ensure accurate code selection and avoid confusion with other Hodgkin lymphoma subtypes
Clinical Significance
Lymphocyte-rich Hodgkin lymphoma involving multiple lymph node sites indicates disseminated disease within a favorable-prognosis subtype. Multi-site involvement requires comprehensive staging and may alter treatment intensity despite the generally good prognosis. The code captures disease affecting two or more distinct nodal regions, which typically corresponds to stage II or higher.
Documentation Requirements
- ✓Pathology confirming lymphocyte-rich classical Hodgkin lymphoma
- ✓Imaging documenting at least two distinct lymph node regions with disease involvement
- ✓Identification of each specific nodal region in clinical documentation
- ✓Complete staging with Ann Arbor classification
- ✓Treatment plan and encounter-specific assessment