C81.41

Billable

Lymphocyte-rich Hodgkin lymphoma, lymph nodes of head, face, and neck

HCC Category Mapping

V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors

0.545

V24HCC 10 — Lymphoma and Other Cancers

0.675

ESRDHCC 10 — Lymphoma and Other Cancers

0.000

RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers

0.000

What This Code Means

A rare type of Hodgkin lymphoma (lymphocyte-rich variant) affecting lymph nodes in the head, face, or neck area.

Coding Tips

•Confirm documentation specifies head, face, or neck lymph node involvement
•This variant has a better prognosis than lymphocyte-depleted Hodgkin lymphoma

Clinical Significance

Lymphocyte-rich Hodgkin lymphoma of head, face, and neck lymph nodes represents a favorable-prognosis subtype in the most common presentation location for Hodgkin lymphoma. Cervical lymphadenopathy is the classic presenting sign, and the lymphocyte-rich subtype carries excellent treatment response rates. Despite favorable biology, these patients require full staging and appropriate treatment to achieve cure.

Documentation Requirements

✓Pathology confirming lymphocyte-rich classical Hodgkin lymphoma (not nodular lymphocyte predominant)
✓Physical exam or imaging documenting head, face, or neck lymph node involvement
✓Specific node groups identified (cervical, supraclavicular, submandibular, occipital)
✓Staging workup results
✓Encounter-specific management documentation

Commonly Confused Codes

C81.01 — Nodular lymphocyte predominant Hodgkin lymphoma, head/face/neck: this is a biologically distinct entity from lymphocyte-rich classical Hodgkin; differentiation requires careful pathologic review C81.11 — Nodular sclerosis Hodgkin lymphoma, head/face/neck: the most common subtype at this location; verify pathology confirms lymphocyte-rich type C81.31 — Lymphocyte depleted Hodgkin lymphoma, head/face/neck: opposite prognosis; pathology must be carefully reviewed

Code Hierarchy

└C81Hodgkin lymphoma └C81.4Lymphocyte-rich Hodgkin lymphoma └C81.41Lymphocyte-rich Hodgkin lymphoma, lymph nodes of head, face, and neck

└C81.41Lymphocyte-rich Hodgkin lymphoma, lymph nodes of head, face, and neck