C81.07
BillableNodular lymphocyte predominant Hodgkin lymphoma, spleen
HCC Category Mapping
V28HCC 21 — Breast, Prostate, Colorectal and Other Cancers and Tumors
0.545V24HCC 10 — Lymphoma and Other Cancers
0.675ESRDHCC 10 — Lymphoma and Other Cancers
0.000RxHCCHCC 21 — Hodgkin Lymphoma and Other Cancers
0.000What This Code Means
Hodgkin lymphoma with nodular lymphocyte predominance that has spread to or originated in the spleen.
Coding Tips
- •Use this code when the spleen is the primary or involved site, not when it's incidental
- •Document whether splenic involvement is primary or secondary to other nodal disease
Clinical Significance
Nodular lymphocyte predominant Hodgkin lymphoma involving the spleen indicates splenic involvement, which is considered extranodal or a separate staging designation in the Ann Arbor system (substage 'S'). Splenic involvement in NLPHL is uncommon and may indicate more advanced disease. The spleen is a lymphoid organ, and its involvement has prognostic significance, potentially requiring splenectomy for both diagnostic and therapeutic purposes.
Documentation Requirements
- ✓Pathology confirming NLPHL subtype
- ✓Imaging or surgical documentation confirming splenic involvement (splenomegaly, focal lesions)
- ✓Whether splenic involvement represents primary splenic disease or extension from adjacent nodes
- ✓Ann Arbor stage with 'S' suffix designation for splenic involvement
- ✓Surgical pathology if splenectomy performed
- ✓Post-splenectomy vaccination status if applicable
Commonly Confused Codes
C81.17 — Nodular sclerosis Hodgkin lymphoma, spleen: Different subtype; pathology determines the correct codeC81.09 — NLPHL, extranodal and solid organ sites: Use C81.07 specifically for splenic involvement; C81.09 covers other extranodal sitesC81.03 — NLPHL, intra-abdominal lymph nodes: Spleen is a separate designation from abdominal lymph nodesD73.89 — Other diseases of spleen: Not a neoplastic code
Code Hierarchy
└C81Hodgkin lymphoma└C81.0Nodular lymphocyte predominant Hodgkin lymphoma└C81.07Nodular lymphocyte predominant Hodgkin lymphoma, spleen
└C81.07Nodular lymphocyte predominant Hodgkin lymphoma, spleen