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C49.A ICD-10-CM Code: Gastrointestinal stromal tumor

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FY 2026 Apr update / Neoplasms (C00-D49) / Malignant neoplasms of mesothelial and soft tissue (C45-C49)

C49.A

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Gastrointestinal stromal tumor

Gastrointestinal stromal tumor

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
C49Malignant neoplasm of other connective and soft tissue
C49.AGastrointestinal stromal tumor

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for C49.A in this effective period.

Excludes 2

Official
  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)

Related Child Codes

Official
C49.A0Gastrointestinal stromal tumor, unspecified site
C49.A1Gastrointestinal stromal tumor of esophagus
C49.A2Gastrointestinal stromal tumor of stomach
C49.A3Gastrointestinal stromal tumor of small intestine
C49.A4Gastrointestinal stromal tumor of large intestine

Includes

Official
  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat

Excludes 1

Official
  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for C49.A in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for C49.A in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for C49.A in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

What This Code Means

C49.A is the ICD-10-CM diagnosis code for gastrointestinal stromal tumor. C49.A sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering malignant neoplasms of mesothelial and soft tissue (c45-c49).

Header codes like C49.A cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at C49.A's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for C49.A sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Child Codes

Code Hierarchy

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