B27.80 ICD-10-CM Code: Other infectious mononucleosis without complication
B27.80 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Other viral diseases (B25-B34)
B27.80
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceOther infectious mononucleosis without complication
Infectious mononucleosis caused by a virus other than Epstein-Barr virus or cytomegalovirus, such as human herpesvirus 6, presenting without complications.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for B27.80. Check the code and parent instructions in the Code Book.
Excludes 2
Official- carrier or suspected carrier of infectious disease (Z22.-)Inherited from A00-B99
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)Inherited from A00-B99
- infectious and parasitic diseases specific to the perinatal period (P35-P39)Inherited from A00-B99
- influenza and other acute respiratory infections (J00-J22)Inherited from A00-B99
Related Codes
Includes
Official- diseases generally recognized as communicable or transmissibleInherited from A00-B99, B27
- glandular feverInherited from A00-B99, B27
- monocytic anginaInherited from A00-B99, B27
- Pfeiffer's diseaseInherited from A00-B99, B27
Excludes 1
Official- certain localized infections - see body system-related chaptersInherited from A00-B99
Code First
OfficialNo Code First sequencing instructions are included in this display for B27.80. Check the code and parent instructions in the Code Book.
Use Additional
Official- code to identify resistance to antimicrobial drugs (Z16.-)Inherited from A00-B99
Code Also
OfficialNo Code Also instructions are included in this display for B27.80. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is B27.80 an HCC code?
No. B27.80 is a billable ICD-10-CM code with no mapping under the current CMS-HCC V28 community payment model, and none under the ESRD, Part D RxHCC, or HHS-HCC models.
- Code
- B27.80
- Description
- Other infectious mononucleosis without complication
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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What This Code Means
B27.80 is the ICD-10-CM diagnosis code for other infectious mononucleosis without complication. Infectious mononucleosis caused by a virus other than Epstein-Barr virus or cytomegalovirus, such as human herpesvirus 6, presenting without complications. B27.80 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering other viral diseases (b25-b34).
B27.80 is a billable ICD-10-CM code, but no current CMS-HCC V28 community payment mapping is shown, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.
Use this code when the causative agent is identified but is not EBV or CMV.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for B27.80 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code when the causative agent is identified but is not EBV or CMV
- •Document the specific viral agent identified in testing to support accurate coding