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B27.00 ICD-10-CM Code: Gammaherpesviral mononucleosis without complication

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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Other viral diseases (B25-B34)

B27.00

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Gammaherpesviral mononucleosis without complication

Infectious mononucleosis caused by Epstein-Barr virus (a type of herpesvirus) presenting with fever, sore throat, and swollen lymph nodes, without additional complications.

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
B27Infectious mononucleosis
B27.0Gammaherpesviral mononucleosis
B27.00Gammaherpesviral mononucleosis without complication

Inclusion Terms

Official
  • Mononucleosis due to Epstein-Barr virus

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for B27.00 in this effective period.

Related Child Codes

Official
B27.01Gammaherpesviral mononucleosis with polyneuropathy
B27.02Gammaherpesviral mononucleosis with meningitis
B27.09Gammaherpesviral mononucleosis with other complications

Includes

Official

ICD-10-CM does not list Includes notes for B27.00 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for B27.00 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for B27.00 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for B27.00 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for B27.00 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance
This code is for uncomplicated EBV mononucleosis; verify no neurological or other complications are present
Document the causative agent (Epstein-Barr virus/gammaherpesvirus) in the medical record for accurate coding

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is B27.00 an HCC code?

No. B27.00 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.

Coder workflow notes

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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

B27.00 is the ICD-10-CM diagnosis code for gammaherpesviral mononucleosis without complication. Infectious mononucleosis caused by Epstein-Barr virus (a type of herpesvirus) presenting with fever, sore throat, and swollen lymph nodes, without additional complications. B27.00 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering other viral diseases (b25-b34).

B27.00 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

This code is for uncomplicated EBV mononucleosis; verify no neurological or other complications are present.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for B27.00 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • This code is for uncomplicated EBV mononucleosis; verify no neurological or other complications are present
  • Document the causative agent (Epstein-Barr virus/gammaherpesvirus) in the medical record for accurate coding

Child Codes

Code Hierarchy

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