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B27.0 ICD-10-CM Code: Gammaherpesviral mononucleosis

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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Other viral diseases (B25-B34)

B27.0

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Gammaherpesviral mononucleosis

Gammaherpesviral mononucleosis

CMS-HCC V28

N/A

Not mapped

CMS-HCC V24

N/A

Not mapped

ACA/HHS

N/A

Not mapped

ESRD/PACE

N/A

Not mapped

RXHCC

N/A

Not mapped

Code Book Path

Official
B27Infectious mononucleosis
B27.0Gammaherpesviral mononucleosis

Inclusion Terms

Official
  • Mononucleosis due to Epstein-Barr virus

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for B27.0 in this effective period.

Related Child Codes

Official
B27.00Gammaherpesviral mononucleosis without complication
B27.01Gammaherpesviral mononucleosis with polyneuropathy
B27.02Gammaherpesviral mononucleosis with meningitis
B27.09Gammaherpesviral mononucleosis with other complications

Includes

Official
  • glandular fever
  • monocytic angina
  • Pfeiffer's disease

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for B27.0 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for B27.0 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for B27.0 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for B27.0 in this effective period.

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Code
B27.0
Description
Gammaherpesviral mononucleosis
HCC (V28)
No CMS-HCC V28 mapping
RAF
Billable
No
Payment year
2026

Coder workflow notes

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What This Code Means

B27.0 is the ICD-10-CM diagnosis code for gammaherpesviral mononucleosis. B27.0 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering other viral diseases (b25-b34).

Header codes like B27.0 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at B27.0's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for B27.0 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Child Codes

Code Hierarchy

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