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A49.01 ICD-10-CM Code: Methicillin susceptible Staphylococcus aureus infection, unspecified site

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FY 2026 Apr update / Certain infectious and parasitic diseases (A00-B99) / Other bacterial diseases (A30-A49)

A49.01

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Methicillin susceptible Staphylococcus aureus infection, unspecified site

This code describes a bacterial infection caused by Staphylococcus aureus (a common bacteria) that responds to methicillin antibiotics, but the specific location of the infection in the body is not documented. It's used when a staph infection is confirmed but the exact site hasn't been specified in the medical record.

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
A49Bacterial infection of unspecified site
A49.0Staphylococcal infection, unspecified site
A49.01Methicillin susceptible Staphylococcus aureus infection, unspecified site

Inclusion Terms

Official
  • Methicillin susceptible Staphylococcus aureus (MSSA) infection
  • Staphylococcus aureus infection NOS

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for A49.01 in this effective period.

Related Child Codes

Official
A49.02Methicillin resistant Staphylococcus aureus infection, unspecified site

Includes

Official

ICD-10-CM does not list Includes notes for A49.01 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for A49.01 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for A49.01 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for A49.01 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for A49.01 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance
Query the provider if a more specific infection site can be identified (such as skin, bone, bloodstream, or respiratory), as this would allow for a more precise code that may affect treatment and reimbursement
Ensure documentation clearly distinguishes between methicillin-susceptible (A49.01) and methicillin-resistant (MRSA, A49.02) strains, as antibiotic resistance significantly impacts clinical management and coding accuracy

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is A49.01 an HCC code?

No. A49.01 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.

Coder workflow notes

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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

A49.01 is the ICD-10-CM diagnosis code for methicillin susceptible staphylococcus aureus infection, unspecified site. This code describes a bacterial infection caused by Staphylococcus aureus (a common bacteria) that responds to methicillin antibiotics, but the specific location of the infection in the body is not documented. It's used when a staph infection is confirmed but the exact site hasn't been specified in the medical record. A49.01 sits in the ICD-10-CM chapter for certain infectious and parasitic diseases (a00-b99), within the section covering other bacterial diseases (a30-a49).

A49.01 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

Query the provider if a more specific infection site can be identified (such as skin, bone, bloodstream, or respiratory), as this would allow for a more precise code that may affect treatment and reimbursement.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for A49.01 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • Query the provider if a more specific infection site can be identified (such as skin, bone, bloodstream, or respiratory), as this would allow for a more precise code that may affect treatment and reimbursement
  • Ensure documentation clearly distinguishes between methicillin-susceptible (A49.01) and methicillin-resistant (MRSA, A49.02) strains, as antibiotic resistance significantly impacts clinical management and coding accuracy

Child Codes

Code Hierarchy

Work A49.01 in HCC Buddy

Open A49.01 in the Code Book for the full Index-to-Tabular path, MEAT checklist, and V28 HCC mapping, or in the Encoder to code from a keyword search. Pro includes 14 days to try everything.