P55.1
BillableABO isoimmunization of newborn
HCC Category Mapping
V28HCC 109 — Hemolytic and Aplastic Anemias
0.291What This Code Means
A condition where the newborn's red blood cells are destroyed by antibodies from the mother due to ABO blood type incompatibility.
Coding Tips
- •ABO incompatibility is more common than Rh but typically causes milder disease
- •Document maternal and infant blood types and antibody titers when available
Clinical Significance
ABO isoimmunization represents maternal-fetal blood group incompatibility leading to hemolysis and potential severe anemia in newborns, requiring immediate monitoring and treatment. This condition can progress to kernicterus if untreated and may require exchange transfusion, making accurate diagnosis and coding essential for care planning.
Documentation Requirements
- ✓Documentation of ABO blood group incompatibility between mother and baby
- ✓Evidence of hemolysis with elevated bilirubin levels
- ✓Maternal antibody testing (anti-A or anti-B antibodies)
- ✓Newborn blood type and direct Coombs test results
- ✓Assessment of anemia severity and hemoglobin levels
- ✓Monitoring for hyperbilirubinemia and kernicterus risk
- ✓Treatment interventions including phototherapy or exchange transfusion
- ✓Serial bilirubin monitoring and response to treatment
Commonly Confused Codes
P55.0 — Rh isoimmunization of newborn (Rh vs ABO incompatibility)P59.3 — Neonatal jaundice due to breast milk inhibitor (feeding vs immune cause)P58.0 — Neonatal jaundice due to bruising (trauma vs immune hemolysis)P55.8 — Other hemolytic diseases of newborn (ABO vs other causes)P59.9 — Neonatal jaundice, unspecified (immune vs non-immune jaundice)
Code Hierarchy
└P55Hemolytic disease of newborn└P55.1ABO isoimmunization of newborn
└P55.1ABO isoimmunization of newborn