P36.4

Billable

Sepsis of newborn due to Escherichia coli

HCC Category Mapping

V28HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

0.455

V24HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

0.455

ESRDHCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock

0.000

What This Code Means

A serious blood infection in a newborn caused by Escherichia coli (E. coli) bacteria.

Coding Tips

•Confirm the organism is E. coli through culture documentation; note any special characteristics such as K1 antigen status if documented
•This is commonly associated with maternal colonization; review maternal history if available

Clinical Significance

E. coli sepsis in newborns represents a serious gram-negative bacterial infection often associated with maternal urogenital tract colonization and early-onset sepsis. This condition carries high morbidity and mortality risk, particularly in premature infants, and requires immediate broad-spectrum antibiotic therapy targeting gram-negative organisms.

Documentation Requirements

✓Positive culture identifying Escherichia coli
✓Clinical manifestations of sepsis
✓Antibiotic susceptibility patterns
✓Extended-spectrum beta-lactamase (ESBL) status if applicable
✓Gestational age and birth weight
✓Maternal risk factors
✓Laboratory markers of infection
✓Treatment response and complications

Commonly Confused Codes

P36.8 — Other bacterial sepsis when organism is different P36.9 — Bacterial sepsis when organism unspecified A41.51 — E. coli sepsis in older patients A49.8 — E. coli infection without sepsis

Code Hierarchy

└P36Bacterial sepsis of newborn └P36.4Sepsis of newborn due to Escherichia coli

└P36.4Sepsis of newborn due to Escherichia coli