G93.43
BillableLeukoencephalopathy with calcifications and cysts
HCC Category Mapping
V28HCC 200 — Cerebellar Ataxia and Other Degenerative Diseases of Nervous System
0.262What This Code Means
A rare inherited brain disorder featuring abnormal white matter with calcium deposits and cyst formation.
Coding Tips
- •Imaging findings of calcifications and cysts are essential for accurate coding of this condition
- •This is a specific leukodystrophy; ensure differentiation from other white matter disorders
Clinical Significance
Leukoencephalopathy with calcifications and cysts (also known as Labrune syndrome) is a rare condition characterized by progressive white matter disease with intracranial calcifications and cyst formation. It can present at any age and causes progressive neurological deterioration including cognitive decline, seizures, and movement disorders. The presence of calcifications and cysts on imaging distinguishes it from other leukoencephalopathies.
Documentation Requirements
- ✓Neuroimaging demonstrating the triad of leukoencephalopathy, calcifications, and cysts
- ✓CT scan showing intracranial calcifications and MRI showing white matter changes
- ✓Clinical documentation of progressive neurological symptoms
- ✓Genetic testing for SNORD118 mutations when available
- ✓Current neurological examination and functional status assessment
Commonly Confused Codes
G93.42 — Megalencephalic leukoencephalopathy with subcortical cysts: different pathology without calcifications, typically childhood onset with macrocephalyG93.44 — Adult-onset leukodystrophy with axonal spheroids: lacks calcifications and cysts, different genetic basisI67.7 — Cerebral arteritis, not elsewhere classified: may have calcifications but represents vascular inflammationE83.52 — Hypercalcemia: metabolic cause of intracranial calcification, not a primary white matter disease
Code Hierarchy
└G93Other disorders of brain└G93.4Other and unspecified encephalopathy└G93.43Leukoencephalopathy with calcifications and cysts
└G93.43Leukoencephalopathy with calcifications and cysts