What is ICD-10 code G65.2?

G65.2 is the ICD-10-CM diagnosis code for Sequelae of toxic polyneuropathy. Long-term complications or residual effects remaining after recovery from nerve damage caused by toxic exposure or poisoning. It belongs to the ICD-10-CM chapter for diseases of the nervous system (g00-g99). G65.2 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. G65.2 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. G65.2 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. G65.2 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for G65.2?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. G65.2 was a payment HCC under V24 (Myasthenia Gravis/Myoneural Disorders and Guillain-Barre Syndrome/Inflammatory and Toxic Neuropathy) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting G65.2?

Link to the specific toxic substance exposure code when available Document the time elapsed since toxic exposure and current functional limitations Because G65.2 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

2026 ICD-10-CM G65.2: Sequelae of toxic

ICD-10-CM Code View

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Code lookupG65.2Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Diseases of the nervous system (G00-G99) / Polyneuropathies and other disorders of the peripheral nervous system (G60-G65)

G65.2

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Sequelae of toxic polyneuropathy

Long-term complications or residual effects remaining after recovery from nerve damage caused by toxic exposure or poisoning.

Buddy Insight

Sequelae of toxic polyneuropathy captures the lasting neurological damage after recovery from toxic substance-induced nerve injury.

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Mapped

HCC 75

Myasthenia Gravis/Myoneural D...

RAF 0.472

ACA/HHS

Mapped

HCC 115

HHS-HCC 115

Varies by metal level

ESRD/PACE

Mapped

HCC 75

Myasthenia Gravis/Myoneural D...

RAF 0.074

RXHCC

Mapped

HCC 158

Guillain-Barre Syndrome and O...

RAF 0.074

Code Book Path

Official

G65Sequelae of inflammatory and toxic polyneuropathies

G65.2Sequelae of toxic polyneuropathy

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for G65.2 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for G65.2 in this effective period.

Related Child Codes

Official

G65.0Sequelae of Guillain-Barre syndrome

G65.1Sequelae of other inflammatory polyneuropathy

Includes

Official

ICD-10-CM does not list Includes notes for G65.2 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for G65.2 in this effective period.

Code First

Official

condition resulting from (sequela) of inflammatory and toxic polyneuropathies

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for G65.2 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for G65.2 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

History of prior toxic polyneuropathy with identification of the causative toxin when known

Documentation that the acute toxic exposure phase has resolved

Current residual neurological deficits: weakness, numbness, pain

Functional limitations resulting from the residual nerve damage

MEAT Support

HCC Buddy guidance

History of prior toxic polyneuropathy with identification of the causative toxin when known

Documentation that the acute toxic exposure phase has resolved

Current residual neurological deficits: weakness, numbness, pain

Functional limitations resulting from the residual nerve damage

Audit Caution

HCC Buddy guidance

Using the active toxic polyneuropathy code when the exposure has ended and only sequelae remain

Failing to document the original toxic agent to support the sequelae diagnosis

Not capturing chemotherapy-induced peripheral neuropathy as sequelae in cancer survivors who have completed treatment

Missing the distinction between ongoing toxic exposure (active code) versus resolved exposure with residual effects (sequelae code)

Common Mistakes

HCC Buddy guidance

G62.0 — Drug-induced polyneuropathy is for the active condition during toxic drug exposure

G62.2 — Polyneuropathy due to other toxic agents is for active toxic neuropathy, not sequelae

G65.0 — Sequelae of Guillain-Barre syndrome is for autoimmune etiology, not toxic

G65.1 — Sequelae of other inflammatory polyneuropathy is for inflammatory etiology, not toxic

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is G65.2 an HCC code?

Yes. G65.2 maps to Myasthenia Gravis/Myoneural Disorders and Guillain-Barre Syndrome/Inflammatory and Toxic Neuropathy under the V24 model but is not retained in V28.

Code: G65.2
Description: Sequelae of toxic polyneuropathy
HCC (V28): No CMS-HCC V28 mapping
RAF: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

V24HCC 75, Myasthenia Gravis/Myoneural Disorders and Guillain-Barre Syndrome/Inflammatory and Toxic Neuropathy

0.472

ESRDHCC 75, Myasthenia Gravis/Myoneural Disorders and Guillain-Barre Syndrome/Inflammatory and Toxic Neuropathy

0.074

RxHCCHCC 158, Guillain-Barre Syndrome and Other Polyneuropathies

0.074

Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work G65.2 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for G65.2

For G65.2to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed G65.2 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

G65.2 is the ICD-10-CM diagnosis code for sequelae of toxic polyneuropathy. Long-term complications or residual effects remaining after recovery from nerve damage caused by toxic exposure or poisoning. G65.2 sits in the ICD-10-CM chapter for diseases of the nervous system (g00-g99), within the section covering polyneuropathies and other disorders of the peripheral nervous system (g60-g65).

Under the older CMS-HCC V24 model, G65.2 maps to Myasthenia Gravis/Myoneural Disorders and Guillain-Barre Syndrome/Inflammatory and Toxic Neuropathy (HCC 75) with a community, non-dual, aged base RAF weight of 0.472. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Link to the specific toxic substance exposure code when available. Because G65.2 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for G65.2 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Link to the specific toxic substance exposure code when available
•Document the time elapsed since toxic exposure and current functional limitations

Clinical Significance

Sequelae of toxic polyneuropathy captures the lasting neurological damage after recovery from toxic substance-induced nerve injury. Patients may experience permanent sensory loss, weakness, or neuropathic pain. This diagnosis reflects the chronic disease burden in patients who have survived toxic exposures, including chemotherapy survivors, and their ongoing functional and therapeutic needs.

Documentation Requirements

✓History of prior toxic polyneuropathy with identification of the causative toxin when known
✓Documentation that the acute toxic exposure phase has resolved
✓Current residual neurological deficits: weakness, numbness, pain
✓Functional limitations resulting from the residual nerve damage
✓Ongoing management for chronic sequelae symptoms
✓Provider's explicit statement linking current deficits to prior toxic polyneuropathy

Commonly Confused Codes

•G62.0: Drug-induced polyneuropathy is for the active condition during toxic drug exposure
•G62.2: Polyneuropathy due to other toxic agents is for active toxic neuropathy, not sequelae
•G65.0: Sequelae of Guillain-Barre syndrome is for autoimmune etiology, not toxic
•G65.1: Sequelae of other inflammatory polyneuropathy is for inflammatory etiology, not toxic