What is ICD-10 code E89.3?

E89.3 is the ICD-10-CM diagnosis code for Postprocedural hypopituitarism. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E89.3 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E89.3 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E89.3 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E89.3 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does E89.3 map to under V28?

E89.3 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for E89.3?

E89.3 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for E89.3?

E89.3 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

What documentation supports E89.3?

This is a postprocedural complication code, so ensure documentation clearly links the hypopituitarism to a prior procedure or treatment Specify which pituitary hormones are deficient (such as growth hormone, thyroid-stimulating hormone, or adrenocorticotropic hormone) with additional codes if documented, as this affects treatment and severity E89.3 is not a CMS-HCC V28 payment code in the verified current source, so MEAT is not the payment hook. Documentation still has to support the diagnosis if you report it.

2026 ICD-10-CM E89.3: Postprocedural hypopituitarism

E89.3 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools

ICD-10-CM Code View

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Code lookupE89.3

Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified (E89)

E89.3

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Postprocedural hypopituitarism

This condition occurs when the pituitary gland (a small gland at the base of the brain that controls many hormones) produces insufficient hormones after a surgical procedure or medical treatment. It results in hormone deficiencies that can affect growth, metabolism, and other body functions.

Buddy Insight

Postprocedural hypopituitarism occurs following pituitary surgery (transsphenoidal or transcranial) or cranial radiation therapy.

Overview Risk Models Code Book Documentation Audit Notes Edition comparison

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

Mapped

HCC 030

HHS-HCC 030 adult, RAF varies...

Code-level coefficient reference

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

Code-level coefficient reference

RXHCC

Mapped

HCC 43

Pituitary, Adrenal Gland, and...

Code-level coefficient reference

Code Book Path

Official

E89Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified E89.3Postprocedural hypopituitarism

Inclusion Terms

Official

Postirradiation hypopituitarism

Excludes 2

Official

intraoperative complications of endocrine system organ or structure (E36.0-, E36.1-, E36.8)Inherited from E89

Related Codes

Official

E89.0Postprocedural hypothyroidism E89.1Postprocedural hypoinsulinemia E89.2Postprocedural hypoparathyroidism E89.4Postprocedural ovarian failure E89.5Postprocedural testicular hypofunction

Includes

Official

No Includes notes are included in this display for E89.3. Check the code and parent instructions in the Code Book.

Excludes 1

Official

transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89

Code First

Official

No Code First sequencing instructions are included in this display for E89.3. Check the code and parent instructions in the Code Book.

Use Additional

Official

No Use Additional Code instructions are included in this display for E89.3. Check the code and parent instructions in the Code Book.

Code Also

Official

No Code Also instructions are included in this display for E89.3. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance

Diagnosis of hypopituitarism attributed to a prior procedure

Type of procedure causing the condition (pituitary surgery, cranial radiation, etc.)

Specific pituitary hormone deficiencies documented (ACTH, TSH, LH/FSH, GH, ADH)

Hormone replacement regimen (hydrocortisone, levothyroxine, testosterone/estrogen, growth hormone, desmopressin)

MEAT Support

HCC Buddy guidance

Diagnosis of hypopituitarism attributed to a prior procedure

Type of procedure causing the condition (pituitary surgery, cranial radiation, etc.)

Specific pituitary hormone deficiencies documented (ACTH, TSH, LH/FSH, GH, ADH)

Hormone replacement regimen (hydrocortisone, levothyroxine, testosterone/estrogen, growth hormone, desmopressin)

Audit Caution

HCC Buddy guidance

Using E23.0 (general hypopituitarism) when the cause is a prior procedure

Not recognizing that radiation-induced hypopituitarism may develop years after treatment

Coding only one hormone deficiency when multiple axes are affected — E89.3 captures the overall pituitary failure

Missing the connection between a prior brain tumor surgery or radiation and current endocrine deficiencies

Common Mistakes

HCC Buddy guidance

E23.0 — Hypopituitarism: non-procedural causes (Sheehan syndrome, tumors, infiltrative diseases)

E23.7 — Disorder of pituitary gland, unspecified: less specific, does not indicate post-procedural cause

E89.0 — Postprocedural hypothyroidism: secondary hypothyroidism from pituitary damage may be coded as E89.3 or E89.0

E89.6 — Postprocedural adrenocortical hypofunction: if only adrenal axis affected by procedure

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E89.3 an HCC code?

E89.3 is not in the CMS-HCC V28 or V24 community payment model. E89.3 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E89.3 also appears in the HHS-HCC commercial risk model (HCC 030 (HHS-HCC 030 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.

Code: E89.3
Description: Postprocedural hypopituitarism
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

Not separately weighted

RxHCCHCC 43, Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work E89.3 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT review for E89.3

For E89.3, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Coder workflow notes

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What This Code Means

E89.3 is the ICD-10-CM diagnosis code for postprocedural hypopituitarism. This condition occurs when the pituitary gland (a small gland at the base of the brain that controls many hormones) produces insufficient hormones after a surgical procedure or medical treatment. It results in hormone deficiencies that can affect growth, metabolism, and other body functions. E89.3 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering postprocedural endocrine and metabolic complications and disorders, not elsewhere classified (e89).

E89.3 has no mapping under the CMS-HCC V28 or V24 community payment models. E89.3 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E89.3 also appears in the HHS-HCC commercial risk model (HCC 030 (HHS-HCC 030 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

This is a postprocedural complication code, so ensure documentation clearly links the hypopituitarism to a prior procedure or treatment.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E89.3 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•This is a postprocedural complication code, so ensure documentation clearly links the hypopituitarism to a prior procedure or treatment
•Specify which pituitary hormones are deficient (such as growth hormone, thyroid-stimulating hormone, or adrenocorticotropic hormone) with additional codes if documented, as this affects treatment and severity

Clinical Significance

Postprocedural hypopituitarism occurs following pituitary surgery (transsphenoidal or transcranial) or cranial radiation therapy. Loss of pituitary function can cause deficiencies in multiple hormones (ACTH, TSH, gonadotropins, growth hormone, ADH), requiring complex multi-hormone replacement therapy and lifelong endocrine monitoring.

Documentation Requirements

✓Diagnosis of hypopituitarism attributed to a prior procedure
✓Type of procedure causing the condition (pituitary surgery, cranial radiation, etc.)
✓Specific pituitary hormone deficiencies documented (ACTH, TSH, LH/FSH, GH, ADH)
✓Hormone replacement regimen (hydrocortisone, levothyroxine, testosterone/estrogen, growth hormone, desmopressin)
✓Monitoring plan with endocrine laboratory schedule
✓Original indication for the pituitary procedure (adenoma, craniopharyngioma)

Commonly Confused Codes

•E23.0: Hypopituitarism: non-procedural causes (Sheehan syndrome, tumors, infiltrative diseases)
•E23.7: Disorder of pituitary gland, unspecified: less specific, does not indicate post-procedural cause
•E89.0: Postprocedural hypothyroidism: secondary hypothyroidism from pituitary damage may be coded as E89.3 or E89.0
•E89.6: Postprocedural adrenocortical hypofunction: if only adrenal axis affected by procedure