E88.82 ICD-10-CM Code: Obesity due to disruption of MC4R pathway
E88.82 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E88.82
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceObesity due to disruption of MC4R pathway
Obesity caused by a genetic defect in the MC4R pathway, which controls appetite and energy expenditure in the brain.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for E88.82. Check the code and parent instructions in the Code Book.
Excludes 2
Official- Ehlers-Danlos syndromes (Q79.6-)Inherited from E70-E88
Related Codes
Includes
OfficialNo Includes notes are included in this display for E88.82. Check the code and parent instructions in the Code Book.
Excludes 1
Official- transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E70-E88, E88
- androgen insensitivity syndrome (E34.5-)Inherited from E00-E89, E70-E88, E88
- congenital adrenal hyperplasia (E25.0)Inherited from E00-E89, E70-E88, E88
- hemolytic anemias attributable to enzyme disorders (D55.-)Inherited from E00-E89, E70-E88, E88
- Marfan syndrome (Q87.4-)Inherited from E00-E89, E70-E88, E88
- 5-alpha-reductase deficiency (E29.1)Inherited from E00-E89, E70-E88, E88
- histiocytosis X (chronic) (C96.6)Inherited from E00-E89, E70-E88, E88
Code First
OfficialNo Code First sequencing instructions are included in this display for E88.82. Check the code and parent instructions in the Code Book.
Use Additional
Official- code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)
- code to identify body mass index (BMI), if known (Z68.-)
- codes for associated conditionsInherited from E88
Code Also
OfficialNo Code Also instructions are included in this display for E88.82. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E88.82 an HCC code?
No. E88.82 is a billable ICD-10-CM code with no mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models.
- Code
- E88.82
- Description
- Obesity due to disruption of MC4R pathway
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E88.82 is the ICD-10-CM diagnosis code for obesity due to disruption of mc4r pathway. Obesity caused by a genetic defect in the MC4R pathway, which controls appetite and energy expenditure in the brain. E88.82 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
E88.82 is a billable ICD-10-CM code, but the current payload does not show a mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.
This code requires documented genetic testing or clinical evidence of MC4R pathway disruption; do not use for common obesity.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E88.82 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.