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E88.02 ICD-10-CM Code: Plasminogen deficiency

E88.02 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC coding software

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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E88.02

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Plasminogen deficiency

A rare blood disorder where the body lacks sufficient plasminogen, a protein needed for breaking down blood clots.

CMS-HCC V28

N/A

—

Not mapped

CMS-HCC V24

Historical

Historical

Not used for CY2026 payment

ACA/HHS

N/A

—

Not mapped

ESRD/PACE

N/A

—

Not mapped

RXHCC

N/A

—

Not mapped

Code Book Path

Official
E88Other and unspecified metabolic disorders
E88.0Disorders of plasma-protein metabolism, not elsewhere classified
E88.02Plasminogen deficiency

Inclusion Terms

Official
  • Dysplasminogenemia
  • Hypoplasminogenemia
  • Type 1 plasminogen deficiency
  • Type 2 plasminogen deficiency

Excludes 2

Official
  • disorder of lipoprotein metabolism (E78.-)

Related Child Codes

Official
E88.01Alpha-1-antitrypsin deficiency
E88.09Other disorders of plasma-protein metabolism, not elsewhere classified

Includes

Official

ICD-10-CM does not list Includes notes for E88.02 in this effective period.

Excludes 1

Official
  • monoclonal gammopathy (of undetermined significance) (D47.2)
  • polyclonal hypergammaglobulinemia (D89.0)
  • Waldenström macroglobulinemia (C88.00)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E88.02 in this effective period.

Use Additional

Official
  • code for associated findings, such as:
  • hydrocephalus (G91.4)
  • otitis media (H67.-)
  • respiratory disorder related to plasminogen deficiency (J99)

Code Also

Official
  • , if applicable, ligneous conjunctivitis (H10.51-)

Buddy Documentation Tip

HCC Buddy guidance
Confirm whether this is congenital or acquired; acquired cases may relate to liver disease or other conditions
Document any thrombotic complications or treatment with plasminogen replacement therapy

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E88.02 an HCC code?

No. E88.02 is a billable ICD-10-CM code with no mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models.

Code
E88.02
Description
Plasminogen deficiency
HCC (V28)
No CMS-HCC V28 mapping
RAF reference coefficient
—
Billable
Yes
Payment year
2026

Coder workflow notes

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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

E88.02 is the ICD-10-CM diagnosis code for plasminogen deficiency. A rare blood disorder where the body lacks sufficient plasminogen, a protein needed for breaking down blood clots. E88.02 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

E88.02 is a billable ICD-10-CM code, but the current payload does not show a mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.

Confirm whether this is congenital or acquired; acquired cases may relate to liver disease or other conditions.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E88.02 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • •Confirm whether this is congenital or acquired; acquired cases may relate to liver disease or other conditions
  • •Document any thrombotic complications or treatment with plasminogen replacement therapy

Use Additional Code

  • code for associated findings, such as:
  • hydrocephalus (G91.4)
  • otitis media (H67.-)
  • respiratory disorder related to plasminogen deficiency (J99)

Code Also

  • , if applicable, ligneous conjunctivitis (H10.51-)

Child Codes

E88.01Alpha-1-antitrypsin deficiency
HCC 50
E88.02Plasminogen deficiency
E88.09Other disorders of plasma-protein metabolism, not elsewhere classified

Code Hierarchy

└E88Other and unspecified metabolic disorders└E88.0Disorders of plasma-protein metabolism, not elsewhere classified└E88.02Plasminogen deficiency
└E88.02Plasminogen deficiency

E88.02 code history

Code setChange
FY2019 (effective Oct 1, 2018)Added to the code set

Source: official CMS ICD-10-CM order and addenda files, FY2016 through FY2027.

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