E84.8 ICD-10-CM Code: Cystic fibrosis with other manifestations
E84.8 maps to CMS-HCC V28 277. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E84.8
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceCystic fibrosis with other manifestations
This code is used for cystic fibrosis when it affects other body systems beyond the lungs and intestines, such as the liver, sweat glands, or reproductive system.
Buddy Insight
Cystic fibrosis with other manifestations captures CF involvement beyond the pulmonary and intestinal systems, including CF-related diabetes, hepatobiliary disease, male infertility, nasal polyps, and musculoskeletal complications.
CMS-HCC V28
MappedHCC 277
Coefficient HCC 277: 0.998 (Community Non-Dual Aged (CNA))
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 159
Code-level coefficient reference
ESRD/PACE
MappedHCC 110
Code-level coefficient reference
RXHCC
MappedHCC 225
Code-level coefficient reference
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for E84.8. Check the code and parent instructions in the Code Book.
Excludes 2
Official- Ehlers-Danlos syndromes (Q79.6-)Inherited from E70-E88
Related Codes
Includes
Official- mucoviscidosisInherited from E84
Excludes 1
Official- transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E70-E88
- androgen insensitivity syndrome (E34.5-)Inherited from E00-E89, E70-E88
- congenital adrenal hyperplasia (E25.0)Inherited from E00-E89, E70-E88
- hemolytic anemias attributable to enzyme disorders (D55.-)Inherited from E00-E89, E70-E88
- Marfan syndrome (Q87.4-)Inherited from E00-E89, E70-E88
- 5-alpha-reductase deficiency (E29.1)Inherited from E00-E89, E70-E88
Code First
OfficialNo Code First sequencing instructions are included in this display for E84.8. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for E84.8. Check the code and parent instructions in the Code Book.
Code Also
Official- exocrine pancreatic insufficiency (K86.81)Inherited from E84
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E84.8 an HCC code?
Yes. E84.8 (Cystic fibrosis with other manifestations) maps to HCC 277, Cystic Fibrosis under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.998. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: E84.8 is billable and maps to V28 HCC 277, Cystic Fibrosis. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- E84.8
- Description
- Cystic fibrosis with other manifestations
- HCC (V28)
- HCC 277 — Cystic Fibrosis
- RAF reference coefficient
- 0.998
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work E84.8 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for E84.8
For E84.8, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
E84.8 is the ICD-10-CM diagnosis code for cystic fibrosis with other manifestations. This code is used for cystic fibrosis when it affects other body systems beyond the lungs and intestines, such as the liver, sweat glands, or reproductive system. E84.8 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
Under the CMS-HCC V28 risk adjustment model, E84.8 maps to Cystic Fibrosis (HCC 277) with a source-labeled community, non-dual, aged reference coefficient of 0.998. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Specify which organ system is affected in documentation to support medical necessity and justify treatment decisions. For E84.8, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E84.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Specify which organ system is affected in documentation to support medical necessity and justify treatment decisions
- •Do not use this code if pulmonary or intestinal manifestations are the primary focus; use more specific codes instead
Clinical Significance
Cystic fibrosis with other manifestations captures CF involvement beyond the pulmonary and intestinal systems, including CF-related diabetes, hepatobiliary disease, male infertility, nasal polyps, and musculoskeletal complications. These multi-system effects reflect the complex nature of CF management.
Documentation Requirements
- ✓Confirmed cystic fibrosis diagnosis
- ✓Specific non-pulmonary, non-intestinal manifestation documented (CF-related diabetes, liver disease, infertility, sinusitis, arthropathy)
- ✓Current management of the specific manifestation
- ✓Explanation of why the manifestation is attributed to CF rather than a separate condition
- ✓Overall CF disease status and complexity documentation
Commonly Confused Codes
- •E84.0: Cystic fibrosis with pulmonary manifestations: for lung involvement specifically
- •E84.19: Cystic fibrosis with other intestinal manifestations: for GI involvement specifically
- •E84.9: Cystic fibrosis, unspecified: less specific; use E84.8 when a specific non-pulmonary/non-GI manifestation is documented
- •E13.9: Other specified diabetes mellitus: CF-related diabetes may use both E84.8 and an E13 code