What is ICD-10 code E83.110?

E83.110 is the ICD-10-CM diagnosis code for Hereditary hemochromatosis. A genetic condition where the body absorbs and stores too much iron from food, leading to organ damage over time. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E83.110 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E83.110 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E83.110 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E83.110 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for E83.110?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. E83.110 was a payment HCC under V24 (Other Significant Endocrine and Metabolic Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting E83.110?

This is the most specific code for hereditary hemochromatosis; use this when the hereditary form is confirmed Verify documentation specifies 'hereditary' or 'genetic' hemochromatosis before assigning this code Because E83.110 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

E83.110: Hereditary hemochromatosis — ICD-10

ICD-10-CM Code View

HCC Buddy Code Card

Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.

Code lookupE83.110Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E83.110

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Hereditary hemochromatosis

A genetic condition where the body absorbs and stores too much iron from food, leading to organ damage over time.

Buddy Insight

Hereditary hemochromatosis is a genetic iron overload disorder that, left untreated, leads to progressive organ damage including cirrhosis, cardiomyopathy, diabetes, and arthropathy.

CMS-HCC V28

Not risk-adjusted for this model/period.

RAF 0

CMS-HCC V24

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.230

ACA/HHS

Not risk-adjusted for this model/period.

RAF 0

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.0

RXHCC

Mapped

HCC 43

Other Significant Endocrine a...

RAF 0.0

Code Trumping

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Compare selected patient codes to show trumped or trumps impact.

Code Book Path

Official

E83.1Disorders of iron metabolism

E83.11Hemochromatosis

E83.110Hereditary hemochromatosis

Inclusion Terms

Official

Bronzed diabetes
Pigmentary cirrhosis (of liver)
Primary (hereditary) hemochromatosis

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E83.110 in this effective period.

Related Child Codes

Official

E83.111Hemochromatosis due to repeated red blood cell transfusions

E83.118Other hemochromatosis

E83.119Hemochromatosis, unspecified

Includes

Official

ICD-10-CM does not list Includes notes for E83.110 in this effective period.

Excludes 1

Official

GALD (P78.84)
Gestational alloimmune liver disease (P78.84)
Neonatal hemochromatosis (P78.84)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E83.110 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E83.110 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E83.110 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Confirmed hereditary/genetic etiology (e.g., HFE gene mutation C282Y or H63D documented)

Serum ferritin and transferrin saturation levels

Current treatment plan (therapeutic phlebotomy schedule or iron chelation)

Documentation of end-organ assessment (liver, heart, pancreas, joints)

MEAT Support

HCC Buddy guidance

Confirmed hereditary/genetic etiology (e.g., HFE gene mutation C282Y or H63D documented)

Serum ferritin and transferrin saturation levels

Current treatment plan (therapeutic phlebotomy schedule or iron chelation)

Documentation of end-organ assessment (liver, heart, pancreas, joints)

Audit Caution

HCC Buddy guidance

Assigning the hereditary code when documentation only states 'hemochromatosis' without specifying hereditary etiology — query the provider

Missing the HCC capture by defaulting to unspecified E83.119 when hereditary type is documented

Failing to link secondary conditions (diabetes, cirrhosis, cardiomyopathy) caused by iron overload as separate reportable diagnoses

Not differentiating between hereditary hemochromatosis and secondary/acquired iron overload from chronic transfusions

Common Mistakes

HCC Buddy guidance

E83.118 — Other hemochromatosis: use when the hemochromatosis is NOT hereditary (e.g., transfusional iron overload)

E83.119 — Hemochromatosis, unspecified: use only when type cannot be determined; less specific and does NOT map to HCC

E83.10 — Disorder of iron metabolism, unspecified: non-specific code that should be avoided when hemochromatosis is documented

E61.1 — Iron deficiency: opposite condition (iron deficiency rather than overload)

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is E83.110 an HCC code?

Yes. E83.110 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 23, Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 43, Other Significant Endocrine and Metabolic Disorders

0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

MEAT Criteria for E83.110

For E83.110to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E83.110 during that encounter, not just copy-forwarded from a problem list.

What This Code Means

E83.110 is the ICD-10-CM diagnosis code for hereditary hemochromatosis. A genetic condition where the body absorbs and stores too much iron from food, leading to organ damage over time. E83.110 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Under the older CMS-HCC V24 model, E83.110 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.230. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

This is the most specific code for hereditary hemochromatosis; use this when the hereditary form is confirmed. Because E83.110 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E83.110 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•This is the most specific code for hereditary hemochromatosis; use this when the hereditary form is confirmed
•Verify documentation specifies 'hereditary' or 'genetic' hemochromatosis before assigning this code

Clinical Significance

Hereditary hemochromatosis is a genetic iron overload disorder that, left untreated, leads to progressive organ damage including cirrhosis, cardiomyopathy, diabetes, and arthropathy. It is a risk-adjustment-relevant condition under CMS-HCC V24 because it reflects ongoing metabolic burden requiring lifelong monitoring and therapeutic phlebotomy.

Documentation Requirements

✓Confirmed hereditary/genetic etiology (e.g., HFE gene mutation C282Y or H63D documented)
✓Serum ferritin and transferrin saturation levels
✓Current treatment plan (therapeutic phlebotomy schedule or iron chelation)
✓Documentation of end-organ assessment (liver, heart, pancreas, joints)
✓Family history supporting hereditary nature

Commonly Confused Codes

•E83.118: Other hemochromatosis: use when the hemochromatosis is NOT hereditary (e.g., transfusional iron overload)
•E83.119: Hemochromatosis, unspecified: use only when type cannot be determined; less specific and does NOT map to HCC
•E83.10: Disorder of iron metabolism, unspecified: non-specific code that should be avoided when hemochromatosis is documented
•E61.1: Iron deficiency: opposite condition (iron deficiency rather than overload)