E79.89
BillableOther specified disorders of purine and pyrimidine metabolism
HCC Category Mapping
V24HCC 23 — Other Significant Endocrine and Metabolic Disorders
0.230ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders
0.000RxHCCHCC 43 — Other Significant Endocrine and Metabolic Disorders
0.000What This Code Means
Other rare inherited disorders affecting the body's ability to process purines and pyrimidines, which are building blocks of DNA.
Coding Tips
- •Use this code only when a specific purine or pyrimidine disorder is not captured by other E79 codes
- •Provide detailed documentation of the specific metabolic disorder identified
Clinical Significance
Other specified disorders of purine and pyrimidine metabolism encompasses named purine/pyrimidine disorders without their own specific ICD-10-CM codes, including adenine phosphoribosyltransferase (APRT) deficiency, Kelley-Seegmiller syndrome (partial HPRT deficiency), and dihydropyrimidine dehydrogenase deficiency. These conditions have varied clinical presentations from kidney stones to severe drug toxicity.
Documentation Requirements
- ✓Specific purine or pyrimidine metabolism disorder documented
- ✓Confirmatory enzyme assay or genetic testing
- ✓Clinical manifestations specific to the disorder (kidney stones for APRT deficiency, hyperuricemia for Kelley-Seegmiller, fluoropyrimidine toxicity for DPD deficiency)
- ✓Treatment plan tailored to the specific deficiency
- ✓Family history and genetic counseling if applicable
Commonly Confused Codes
E79.1 — Lesch-Nyhan syndrome: complete HPRT deficiency with neurological features, has its own codeE79.2 — Myoadenylate deaminase deficiency: has its own specific codeE79.81 — Aicardi-Goutieres syndrome: has its own specific codeE79.82 — Hereditary xanthinuria: has its own specific codeE79.9 — Disorder of purine and pyrimidine metabolism, unspecified: use only when no specific disorder is identified