What is ICD-10 code E76.9?

E76.9 is the ICD-10-CM diagnosis code for Glucosaminoglycan metabolism disorder, unspecified. Glucosaminoglycan metabolism disorder, unspecified, is used when a patient has a disorder affecting how the body processes complex sugars but the specific type cannot be identified. E76.9 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E76.9 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E76.9 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E76.9 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does E76.9 map to under V28?

E76.9 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for E76.9?

E76.9 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for E76.9?

E76.9 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

What documentation supports E76.9?

This is the least specific code in the glucosaminoglycan metabolism category; pursue additional diagnostic information when possible Use only when no more specific diagnosis code can be determined from the clinical documentation E76.9 is not a CMS-HCC V28 payment code in the verified current source, so MEAT is not the payment hook. Documentation still has to support the diagnosis if you report it.

2026 ICD-10-CM E76.9: Glucosaminoglycan metabolism disorder

E76.9 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · free HCC coding tools

ICD-10-CM Code View

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Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.

Code lookupE76.9

Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E76.9

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Glucosaminoglycan metabolism disorder, unspecified

Glucosaminoglycan metabolism disorder, unspecified, is used when a patient has a disorder affecting how the body processes complex sugars but the specific type cannot be identified.

Buddy Insight

Glucosaminoglycan metabolism disorder, unspecified is used when abnormal GAG metabolism is confirmed but the specific disorder has not been identified.

Overview Risk Models Code Book Documentation Audit Notes Edition comparison

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

Mapped

HCC 026

HHS-HCC 026 adult, RAF varies...

Code-level coefficient reference

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

Code-level coefficient reference

RXHCC

Mapped

HCC 43

Pituitary, Adrenal Gland, and...

Code-level coefficient reference

Code Book Path

Official

E76Disorders of glycosaminoglycan metabolism E76.9Glucosaminoglycan metabolism disorder, unspecified

Inclusion Terms

Official

No inclusion terms are included in this display for E76.9. Check the code and parent instructions in the Code Book.

Excludes 2

Official

Ehlers-Danlos syndromes (Q79.6-)Inherited from E70-E88

Related Codes

Official

E76.0Mucopolysaccharidosis, type I E76.1Mucopolysaccharidosis, type II E76.2Other mucopolysaccharidoses E76.3Mucopolysaccharidosis, unspecified E76.8Other disorders of glucosaminoglycan metabolism

Includes

Official

No Includes notes are included in this display for E76.9. Check the code and parent instructions in the Code Book.

Excludes 1

Official

transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E70-E88
androgen insensitivity syndrome (E34.5-)Inherited from E00-E89, E70-E88
congenital adrenal hyperplasia (E25.0)Inherited from E00-E89, E70-E88
hemolytic anemias attributable to enzyme disorders (D55.-)Inherited from E00-E89, E70-E88
Marfan syndrome (Q87.4-)Inherited from E00-E89, E70-E88
5-alpha-reductase deficiency (E29.1)Inherited from E00-E89, E70-E88

Code First

Official

No Code First sequencing instructions are included in this display for E76.9. Check the code and parent instructions in the Code Book.

Use Additional

Official

No Use Additional Code instructions are included in this display for E76.9. Check the code and parent instructions in the Code Book.

Code Also

Official

No Code Also instructions are included in this display for E76.9. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance

Provider documentation of confirmed or suspected GAG metabolism disorder

Supporting clinical or laboratory evidence (elevated urine GAGs, clinical features suggestive of storage disorder)

Reason for lack of specificity (evaluation in progress, atypical results)

Plan for further diagnostic evaluation

MEAT Support

HCC Buddy guidance

Provider documentation of confirmed or suspected GAG metabolism disorder

Supporting clinical or laboratory evidence (elevated urine GAGs, clinical features suggestive of storage disorder)

Reason for lack of specificity (evaluation in progress, atypical results)

Plan for further diagnostic evaluation

Audit Caution

HCC Buddy guidance

Using E76.9 when a more specific GAG metabolism disorder code is supported by the documentation

Not recognizing that elevated urine GAGs alone do not confirm a specific MPS diagnosis

Failing to query the provider for clarification when enzyme or genetic results are available

Using this code long-term without follow-up to obtain a more specific diagnosis

Common Mistakes

HCC Buddy guidance

E76.3 — Mucopolysaccharidosis, unspecified: more specific than E76.9 when MPS IS confirmed but type unknown

E76.8 — Other disorders of glucosaminoglycan metabolism: for identified non-MPS GAG disorders

E88.9 — Metabolic disorder, unspecified: even broader and should not be used when GAG involvement is known

E76.01-E76.29 — Specific MPS types: use whenever the type is identified

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E76.9 an HCC code?

E76.9 is not in the CMS-HCC V28 or V24 community payment model. E76.9 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E76.9 also appears in the HHS-HCC commercial risk model (HCC 026 (HHS-HCC 026 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.

Code: E76.9
Description: Glucosaminoglycan metabolism disorder, unspecified
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

Not separately weighted

RxHCCHCC 43, Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work E76.9 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT review for E76.9

For E76.9, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Coder workflow notes

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What This Code Means

E76.9 is the ICD-10-CM diagnosis code for glucosaminoglycan metabolism disorder, unspecified. Glucosaminoglycan metabolism disorder, unspecified, is used when a patient has a disorder affecting how the body processes complex sugars but the specific type cannot be identified. E76.9 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

E76.9 has no mapping under the CMS-HCC V28 or V24 community payment models. E76.9 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E76.9 also appears in the HHS-HCC commercial risk model (HCC 026 (HHS-HCC 026 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

This is the least specific code in the glucosaminoglycan metabolism category; pursue additional diagnostic information when possible.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E76.9 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•This is the least specific code in the glucosaminoglycan metabolism category; pursue additional diagnostic information when possible
•Use only when no more specific diagnosis code can be determined from the clinical documentation

Clinical Significance

Glucosaminoglycan metabolism disorder, unspecified is used when abnormal GAG metabolism is confirmed but the specific disorder has not been identified. This is a broad code that may capture early diagnostic evaluations for suspected MPS or other GAG disorders before definitive testing is complete.

Documentation Requirements

✓Provider documentation of confirmed or suspected GAG metabolism disorder
✓Supporting clinical or laboratory evidence (elevated urine GAGs, clinical features suggestive of storage disorder)
✓Reason for lack of specificity (evaluation in progress, atypical results)
✓Plan for further diagnostic evaluation
✓Current symptom management

Commonly Confused Codes

•E76.3: Mucopolysaccharidosis, unspecified: more specific than E76.9 when MPS IS confirmed but type unknown
•E76.8: Other disorders of glucosaminoglycan metabolism: for identified non-MPS GAG disorders
•E88.9: Metabolic disorder, unspecified: even broader and should not be used when GAG involvement is known
•E76.01-E76.29: Specific MPS types: use whenever the type is identified