E74.810

HCC Category Mapping

What This Code Means

This is a rare genetic disorder where the body cannot properly transport glucose (sugar) into the brain due to a defective protein. This causes low blood sugar levels in the brain, leading to seizures, developmental delays, and movement problems.

Coding Tips

• •This is a specific metabolic disorder code that requires documentation of the glucose transporter protein type 1 deficiency diagnosis; do not use more general glucose metabolism codes
• •This condition is often associated with seizures and neurological symptoms, so review documentation for additional codes related to epilepsy or neurological manifestations that should be coded separately

Clinical Significance

Glucose transporter protein type 1 (GLUT1) deficiency syndrome is a genetic neurometabolic disorder where impaired glucose transport across the blood-brain barrier results in cerebral energy failure. Patients develop epilepsy (often drug-resistant), developmental delay, acquired microcephaly, and complex movement disorders. The ketogenic diet is the primary treatment, providing ketone bodies as an alternative brain fuel source.

Documentation Requirements

• ✓Confirmed diagnosis of GLUT1 deficiency syndrome
• ✓Low cerebrospinal fluid glucose with normal blood glucose (hypoglycorrhachia)
• ✓SLC2A1 gene mutation analysis results
• ✓Documentation of seizure type and frequency
• ✓Ketogenic diet implementation and adherence status
• ✓Neurological assessment including developmental milestones and movement disorder evaluation

Commonly Confused Codes