E71.548 ICD-10-CM Code: Other peroxisomal disorders
HCC Buddy Code Card
Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.
FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E71.548
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceOther peroxisomal disorders
Other rare inherited metabolic disorders affecting peroxisome function that do not fit into the main peroxisomal disorder categories.
Buddy Insight
This residual code captures peroxisomal disorders not classified in other E71.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
MappedHCC 23
RAF 0.194
ACA/HHS
MappedHCC 28
Varies by metal level
ESRD/PACE
MappedHCC 23
RAF 0.036
RXHCC
MappedHCC 43
RAF 0.063
Code Book Path
Inclusion Terms
OfficialICD-10-CM does not list inclusion terms for E71.548 in this effective period.
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E71.548 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E71.548 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for E71.548 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E71.548 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E71.548 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E71.548 in this effective period.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E71.548 an HCC code?
Yes. E71.548 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.
- Code
- E71.548
- Description
- Other peroxisomal disorders
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF
- —
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
Work E71.548 in the Code Book — tabular path, V28 RAF, and MEAT checklist →
MEAT Criteria for E71.548
For E71.548 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E71.548 during that encounter, not just copy-forwarded from a problem list.
Coder workflow notes
Get the V28 RAF + MEAT cheat sheet
One printable page: confirm a code's V28 HCC status, its RAF weight, and the MEAT your note needs to make it stick. Free, no card.
Free PDF. No card. Unsubscribe anytime.
What This Code Means
E71.548 is the ICD-10-CM diagnosis code for other peroxisomal disorders. Other rare inherited metabolic disorders affecting peroxisome function that do not fit into the main peroxisomal disorder categories. E71.548 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
Under the older CMS-HCC V24 model, E71.548 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.194. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.
This is a catch-all code for peroxisomal disorders not classified elsewhere; use only when more specific codes do not apply. Because E71.548 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E71.548 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This is a catch-all code for peroxisomal disorders not classified elsewhere; use only when more specific codes do not apply
- •Document the specific peroxisomal disorder identified to support medical necessity
Clinical Significance
This residual code captures peroxisomal disorders not classified in other E71.5 subcategories, including rare single-enzyme defects or newly identified peroxisomal conditions not yet assigned specific codes. Peroxisomal disorders in this category may affect fatty acid chain shortening, ether lipid synthesis, or other specific peroxisomal functions. Clinical presentation depends on the specific pathway affected.
Documentation Requirements
- ✓Document the specific peroxisomal disorder identified, biochemical testing results confirming peroxisomal dysfunction, affected metabolic pathway, genetic testing if available, clinical manifestations, and reason why a more specific peroxisomal code does not apply.
- ✓Record current management approach.