FY2027 ICD-10-CM reference
E70.321: Tyrosinase positive oculocutaneous albinism
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Tyrosinase positive oculocutaneous albinism. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Billable code. Verified against the official FY2027 order file.
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Instructional note
All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: E00-E89 (chapter, inherited).
Excludes1
transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Source: E00-E89 (chapter, inherited).
Excludes1
androgen insensitivity syndrome (E34.5-)
Source: E70-E88 (section, inherited).
Excludes1
congenital adrenal hyperplasia (E25.0)
Source: E70-E88 (section, inherited).
Excludes1
hemolytic anemias attributable to enzyme disorders (D55.-)
Source: E70-E88 (section, inherited).
Excludes1
Marfan syndrome (Q87.4-)
Source: E70-E88 (section, inherited).
Excludes1
5-alpha-reductase deficiency (E29.1)
Source: E70-E88 (section, inherited).
Excludes2
Ehlers-Danlos syndromes (Q79.6-)
Source: E70-E88 (section, inherited).
Excludes1
Chediak-Higashi syndrome (E70.330)
Source: E70.32 (self, inherited).
Excludes1
Hermansky-Pudlak syndrome (E70.331)
Source: E70.32 (self, inherited).
Instructional note
Albinism II
Source: E70.321 (self, direct).
Instructional note
Oculocutaneous albinism ty-pos
Source: E70.321 (self, direct).
Compare the FY2027 additions, removals and billable-status changes
What does E70.321 mean in FY2027?
The official ICD-10-CM descriptor is Tyrosinase positive oculocutaneous albinism. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is E70.321 billable in FY2027?
The FY2027 order file marks E70.321 as billable. Check the complete Tabular instructions and documentation before assigning it.
Does E70.321 map to an HCC?
E70.321 has no CMS-HCC V28 category in the CMS 2027 Initial ICD-10-CM Mappings (payment year 2027, 2026 dates of service). Under the PY2026 CMS mapping; CMS 2027 initial file unchanged: ESRD HCC 23 (CMS lists the same category for every age band in its model mapping); RxHCC HCC 43. Coefficients for these models are pending verification for payment year 2027. HHS-HCC: HCC 28 (This code has a CMS age requirement: applies when age < 21) under the HHS-HCC 2026 benefit year mapping (no RAF; HHS-HCC weights vary by metal level). CMS-HCC V24: not used for payment year 2027 Medicare Advantage payment (CMS CY 2027 Rate Announcement). The PACE mapping is still pending verification for FY2027.
Source: CMS FY2027 ICD-10-CM order file. Payment model: CMS CY 2027 Rate Announcement. Read the FY2027 Official Guidelines.
Review the FY2026 April edition
