E27.5

Billable

Adrenomedullary hyperfunction

HCC Category Mapping

V24HCC 23 — Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 43 — Other Significant Endocrine and Metabolic Disorders

0.000

What This Code Means

Overproduction of hormones from the inner portion of the adrenal gland, particularly epinephrine and norepinephrine.

Coding Tips

•Often associated with pheochromocytoma; verify if a tumor code should be assigned separately
•Document symptoms such as hypertension, palpitations, or sweating that may indicate this condition

Clinical Significance

Adrenomedullary hyperfunction involves excessive catecholamine production (epinephrine and norepinephrine) from the adrenal medulla, most commonly caused by pheochromocytoma. This condition causes paroxysmal or sustained hypertension, tachycardia, diaphoresis, and headaches, with risk of hypertensive crisis, stroke, and cardiac arrhythmias.

Documentation Requirements

✓Document plasma or urine catecholamine and metanephrine levels, imaging confirming adrenal medullary pathology, symptom profile (hypertension, palpitations, diaphoresis, headache), surgical plans, and preoperative alpha-blockade regimen.

Code Also

, if applicable:
malignant pheochromocytoma (C74.1-)
pheochromocytoma (benign) (D35.0-)
secondary hypertension (I15.2)

Commonly Confused Codes

E27.0 (adrenocortical overactivity affecting cortical hormones, not medullary catecholamines), D35.0 (benign neoplasm of adrenal gland if pheochromocytoma is benign), C74.1 (malignant neoplasm of adrenal medulla if malignant), I10 (essential hypertension masking the endocrine cause).

Code Hierarchy

└E27Other disorders of adrenal gland └E27.5Adrenomedullary hyperfunction

└E27.5Adrenomedullary hyperfunction