E03.2 ICD-10-CM Code: Hypothyroidism due to medicaments and other exogenous substances
E03.2 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of thyroid gland (E00-E07)
E03.2
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceHypothyroidism due to medicaments and other exogenous substances
Low thyroid function caused by medications or other external substances that interfere with thyroid hormone production or function.
Buddy Insight
Hypothyroidism due to medicaments and other exogenous substances is an iatrogenic condition caused by medications or external agents that suppress thyroid function.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
MappedHCC 44
Code-level coefficient reference
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for E03.2. Check the code and parent instructions in the Code Book.
Excludes 2
OfficialNo Excludes 2 notes are included in this display for E03.2. Check the code and parent instructions in the Code Book.
Related Codes
Includes
OfficialNo Includes notes are included in this display for E03.2. Check the code and parent instructions in the Code Book.
Excludes 1
Official- transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E03
- iodine-deficiency related hypothyroidism (E00-E02)Inherited from E00-E89, E03
- postprocedural hypothyroidism (E89.0)Inherited from E00-E89, E03
Code First
Official- poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)
Use Additional
Official- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Code Also
OfficialNo Code Also instructions are included in this display for E03.2. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E03.2 an HCC code?
E03.2 has no mapping under the current CMS-HCC V28 community payment model. E03.2 has a separate mapping under the Part D RxHCC model (HCC 44 (Thyroid Disorders)); the applicable result needs member context.
- Code
- E03.2
- Description
- Hypothyroidism due to medicaments and other exogenous substances
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work E03.2 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for E03.2
For E03.2, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
E03.2 is the ICD-10-CM diagnosis code for hypothyroidism due to medicaments and other exogenous substances. Low thyroid function caused by medications or other external substances that interfere with thyroid hormone production or function. E03.2 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of thyroid gland (e00-e07).
E03.2 has no mapping under the current CMS-HCC V28 community payment model. E03.2 has a separate mapping under the Part D RxHCC model (HCC 44 (Thyroid Disorders)); the applicable result needs member context. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.
Identify and document the specific medication or substance causing the hypothyroidism (e.g., amiodarone, lithium, iodine contrast).
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E03.2 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Identify and document the specific medication or substance causing the hypothyroidism (e.g., amiodarone, lithium, iodine contrast)
- •Include the drug name in the medical record and consider using an additional code for the adverse effect if applicable
Clinical Significance
Hypothyroidism due to medicaments and other exogenous substances is an iatrogenic condition caused by medications or external agents that suppress thyroid function. Common causative agents include amiodarone, lithium, interferon-alpha, tyrosine kinase inhibitors, and immune checkpoint inhibitors. Recognition of the medication-induced etiology is critical because management may involve dose adjustment, drug discontinuation, or thyroid hormone replacement while continuing the necessary medication.
Documentation Requirements
- ✓Documentation must identify the specific causative medication or exogenous substance and establish the causal relationship to the hypothyroidism.
- ✓Thyroid function tests before and after medication initiation, the clinical decision regarding continuing or discontinuing the offending agent, and any thyroid replacement therapy should be documented.
- ✓An additional adverse effect code (T36-T65) should be assigned to identify the specific substance.
Use Additional Code
Commonly Confused Codes
- •E03.9 (Hypothyroidism, unspecified) does not capture the iatrogenic etiology.
- •E03.3 (Postinfectious hypothyroidism) has a different causative mechanism.
- •E06.4 (Drug-induced thyroiditis) captures inflammatory thyroid damage from medications rather than direct suppression of thyroid function.
- •E03.8 (Other specified hypothyroidism) captures other non-medication causes.