What is ICD-10 code D82.8?

D82.8 is the ICD-10-CM diagnosis code for Immunodeficiency associated with other specified major defects. An immunodeficiency condition linked to other significant genetic or developmental abnormalities not covered by more specific codes. D82.8 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. D82.8 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. D82.8 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. D82.8 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does D82.8 map to under V28?

D82.8 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for D82.8?

D82.8 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for D82.8?

D82.8 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

What documentation supports D82.8?

Use this code only when the major defect is specified but doesn't fit other D82 categories Document the associated major defect clearly in the medical record for specificity D82.8 is not a CMS-HCC V28 payment code in the verified current source, so MEAT is not the payment hook. Documentation still has to support the diagnosis if you report it.

2026 ICD-10-CM D82.8: Immunodeficiency associated with other

D82.8 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools

ICD-10-CM Code View

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Code lookupD82.8Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Certain disorders involving the immune mechanism (D80-D89)

D82.8

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Immunodeficiency associated with other specified major defects

An immunodeficiency condition linked to other significant genetic or developmental abnormalities not covered by more specific codes.

Buddy Insight

Immunodeficiency associated with other specified major defects encompasses rare syndromic immunodeficiency disorders with defined genetic or developmental abnormalities that do not fit the specific categories of Wiskott-Aldrich, DiGeorge, short-limbed immunodeficiency, or Epstein-Barr virus susceptibility syndromes.

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

Mapped

HCC 074

HHS-HCC 074 adult, RAF varies...

Code-level coefficient reference

ESRD/PACE

Mapped

HCC 47

Disorders of Immunity

Code-level coefficient reference

RXHCC

Mapped

HCC 99

Immune Disorders

Code-level coefficient reference

Code Book Path

Official

D82Immunodeficiency associated with other major defects

D82.8Immunodeficiency associated with other specified major defects

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for D82.8 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for D82.8 in this effective period.

Related Child Codes

Official

D82.0Wiskott-Aldrich syndrome

D82.1Di George's syndrome

D82.2Immunodeficiency with short-limbed stature

D82.3Immunodeficiency following hereditary defective response to Epstein-Barr virus

D82.4Hyperimmunoglobulin E [IgE] syndrome

Includes

Official

ICD-10-CM does not list Includes notes for D82.8 in this effective period.

Excludes 1

Official

ataxia telangiectasia [Louis-Bar] (G11.3)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D82.8 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D82.8 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for D82.8 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Documentation must specify the particular major defect associated with the immunodeficiency, include genetic testing confirming the underlying condition, immunological assessment showing the specific immune deficits, and description of the associated non-immune features.

Document the relationship between the major defect and the immunodeficiency to support code assignment.

MEAT Support

HCC Buddy guidance

Document the relationship between the major defect and the immunodeficiency to support code assignment.

Audit Caution

HCC Buddy guidance

Ensure the documented major defect is truly associated with immunodeficiency and not a coincidental finding.

For ataxia-telangiectasia, code the neurological manifestation separately (G11.3).

This code should not be used for immunodeficiency due to medications or external causes, which have their own specific codes (D84.821, D84.822).

Verify the defect does not fit D82.0-D82.4 before using this code.

Common Mistakes

HCC Buddy guidance

D82.0 through D82.4 (specific syndromic immunodeficiencies that should be used when applicable), D82.9 (immunodeficiency associated with major defect, unspecified), D81.89 (other combined immunodeficiencies without associated major defects), G11.3 (ataxia-telangiectasia which has its own neurological code but may also require D82.8 for the immune component).

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is D82.8 an HCC code?

D82.8 is not in the CMS-HCC V28 or V24 community payment model. D82.8 has a separate mapping under the CMS-HCC ESRD model (HCC 47 (Disorders of Immunity)) and the Part D RxHCC model (HCC 99 (Immune Disorders)); the applicable result needs member context. D82.8 also appears in the HHS-HCC commercial risk model (HCC 074 (HHS-HCC 074 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.

Code: D82.8
Description: Immunodeficiency associated with other specified major defects
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

ESRDHCC 47, Disorders of Immunity

Not separately weighted

RxHCCHCC 99, Immune Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work D82.8 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT Criteria for D82.8

For D82.8 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed D82.8 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

D82.8 is the ICD-10-CM diagnosis code for immunodeficiency associated with other specified major defects. An immunodeficiency condition linked to other significant genetic or developmental abnormalities not covered by more specific codes. D82.8 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).

D82.8 has no mapping under the CMS-HCC V28 or V24 community payment models. D82.8 has a separate mapping under the CMS-HCC ESRD model (HCC 47 (Disorders of Immunity)) and the Part D RxHCC model (HCC 99 (Immune Disorders)); the applicable result needs member context. D82.8 also appears in the HHS-HCC commercial risk model (HCC 074 (HHS-HCC 074 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

Use this code only when the major defect is specified but doesn't fit other D82 categories.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D82.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Use this code only when the major defect is specified but doesn't fit other D82 categories
•Document the associated major defect clearly in the medical record for specificity

Clinical Significance

Documentation Requirements

✓Documentation must specify the particular major defect associated with the immunodeficiency, include genetic testing confirming the underlying condition, immunological assessment showing the specific immune deficits, and description of the associated non-immune features.
✓Document the relationship between the major defect and the immunodeficiency to support code assignment.

Commonly Confused Codes

•D82.0 through D82.4 (specific syndromic immunodeficiencies that should be used when applicable), D82.9 (immunodeficiency associated with major defect, unspecified), D81.89 (other combined immunodeficiencies without associated major defects), G11.3 (ataxia-telangiectasia which has its own neurological code but may also require D82.8 for the immune component).