D72.823
BillableLeukemoid reaction
Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)
Is D72.823 an HCC code?
No. D72.823 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
D72.823 is the ICD-10-CM diagnosis code for leukemoid reaction. A temporary increase in white blood cells that mimics leukemia but is actually a normal response to infection, inflammation, stress, or medications. The white blood cell count returns to normal once the triggering condition resolves. D72.823 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering other disorders of blood and blood-forming organs (d70-d77).
D72.823 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Document the underlying cause (infection, stress, medication) that triggered the leukemoid reaction.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D72.823 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document the underlying cause (infection, stress, medication) that triggered the leukemoid reaction
- •Distinguish this from actual leukemia; leukemoid reactions are reversible and resolve with treatment of the underlying cause