D70.3

Billable

Neutropenia due to infection

HCC Category Mapping

V24HCC 47 — Disorders of Immunity

0.472

ESRDHCC 47 — Disorders of Immunity

0.000

What This Code Means

A temporary decrease in white blood cells that occurs as the body fights off an infection.

Coding Tips

•Code the underlying infection separately; this code explains the mechanism of the low white cell count
•Verify that the neutropenia is directly related to the infection and not from other causes

Clinical Significance

Neutropenia due to infection captures reduced neutrophil counts directly caused by infectious agents, most commonly viral infections (HIV, hepatitis, EBV, CMV, parvovirus B19) and overwhelming bacterial sepsis. The mechanism may involve direct bone marrow suppression, immune-mediated neutrophil destruction, or margination and consumption. It is typically self-limited once the infection resolves.

Documentation Requirements

✓Document the causative infectious agent, absolute neutrophil count, temporal relationship between infection and neutropenia onset, and whether the neutropenia resolved with treatment of the infection.
✓Record any secondary bacterial infections complicating the neutropenic period and treatment provided.

Commonly Confused Codes

D70.1-D70.2 (Drug-induced agranulocytosis) — medication-related rather than infection-related D70.8 (Other neutropenia) — non-infectious acquired neutropenia B20 (HIV disease) — when HIV is the underlying cause, code both the HIV and the neutropenia.

Code Hierarchy

└D70Neutropenia └D70.3Neutropenia due to infection

└D70.3Neutropenia due to infection