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D68.69 ICD-10-CM Code: Other thrombophilia

ICD-10-CM Code View

HCC Buddy Code Card

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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)

D68.69

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other thrombophilia

Other autoimmune or acquired conditions affecting blood clotting that increase clot formation risk, not classified elsewhere.

Buddy the Bee presenting code insight

Buddy Insight

Other thrombophilia captures acquired or secondary thrombophilic states not classified elsewhere, including hyperhomocysteinemia-associated thrombophilia, nephrotic syndrome-related hypercoagulability, malignancy-associated thrombophilia, and elevated factor VIII levels associated with thrombotic risk.

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

HCC 48

RAF 0.209

ACA/HHS

0

0

RAF 0

ESRD/PACE

HCC 48

RAF 0.0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
D68Other coagulation defects
D68.6Other thrombophilia
D68.69Other thrombophilia

Inclusion Terms

Official
  • COVID-19 associated hypercoagulability
  • Hypercoagulable states NEC
  • Secondary hypercoagulable state NOS

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for D68.69 in this effective period.

Related Child Codes

Official
D68.61Antiphospholipid syndrome
D68.62Lupus anticoagulant syndrome

Includes

Official

ICD-10-CM does not list Includes notes for D68.69 in this effective period.

Excludes 1

Official
  • diffuse or disseminated intravascular coagulation [DIC] (D65)
  • heparin induced thrombocytopenia (HIT) (D75.82-)
  • hyperhomocysteinemia (E72.11)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D68.69 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D68.69 in this effective period.

Code Also

Official
  • , if applicable, associated condition

Buddy Documentation Tip

HCC Buddy guidance
Document the specific underlying thrombophilic condition, laboratory evidence supporting the diagnosis (homocysteine levels, factor VIII levels, coagulation studies), personal thrombotic history, and current treatment or prophylaxis strategy.
Record the underlying cause if secondary (malignancy, nephrotic syndrome).

MEAT Support

HCC Buddy guidance
Document the specific underlying thrombophilic condition, laboratory evidence supporting the diagnosis (homocysteine levels, factor VIII levels, coagulation studies), personal thrombotic history, and current treatment or prophylaxis strategy.
Record the underlying cause if secondary (malignancy, nephrotic syndrome).

Audit Caution

HCC Buddy guidance
Distinguish between primary (inherited) thrombophilia (D68.59) and secondary/acquired thrombophilia (D68.69).
Always code the underlying condition causing the secondary hypercoagulable state.
Hyperhomocysteinemia should be documented with specific levels and whether it responds to B-vitamin supplementation.

Common Mistakes

HCC Buddy guidance
D68.59 (Other primary thrombophilia) — for inherited conditions specifically
D68.61 (Antiphospholipid syndrome) — has its own specific code
D68.51-D68.52 (APC resistance, prothrombin mutation) — specific inherited thrombophilias with dedicated codes.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is D68.69 an HCC code?

Yes. D68.69 maps to Coagulation Defects and Other Specified Hematological Disorders under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 48, Coagulation Defects and Other Specified Hematological Disorders
0.209
ESRDHCC 48, Coagulation Defects and Other Specified Hematological Disorders
0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work D68.69 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for D68.69

For D68.69to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed D68.69 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

D68.69 is the ICD-10-CM diagnosis code for other thrombophilia. Other autoimmune or acquired conditions affecting blood clotting that increase clot formation risk, not classified elsewhere. D68.69 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering coagulation defects, purpura and other hemorrhagic conditions (d65-d69).

Under the older CMS-HCC V24 model, D68.69 maps to Coagulation Defects and Other Specified Hematological Disorders (HCC 48) with a community, non-dual, aged base RAF weight of 0.209. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Use this code for thrombophilias secondary to autoimmune conditions or other acquired causes not specifically listed. Because D68.69 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D68.69 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • Use this code for thrombophilias secondary to autoimmune conditions or other acquired causes not specifically listed
  • Document the underlying autoimmune condition (e.g., SLE, antiphospholipid syndrome variants) for complete coding

Clinical Significance

Other thrombophilia captures acquired or secondary thrombophilic states not classified elsewhere, including hyperhomocysteinemia-associated thrombophilia, nephrotic syndrome-related hypercoagulability, malignancy-associated thrombophilia, and elevated factor VIII levels associated with thrombotic risk. These conditions represent a heterogeneous group of prothrombotic states requiring individualized management.

Documentation Requirements

  • Document the specific underlying thrombophilic condition, laboratory evidence supporting the diagnosis (homocysteine levels, factor VIII levels, coagulation studies), personal thrombotic history, and current treatment or prophylaxis strategy.
  • Record the underlying cause if secondary (malignancy, nephrotic syndrome).

Code Also

  • , if applicable, associated condition

Commonly Confused Codes

  • D68.59 (Other primary thrombophilia): for inherited conditions specifically
  • D68.61 (Antiphospholipid syndrome): has its own specific code
  • D68.51-D68.52 (APC resistance, prothrombin mutation): specific inherited thrombophilias with dedicated codes.

Child Codes

Code Hierarchy

Because D68.69 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

Work D68.69 in HCC Buddy

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