D56.3 ICD-10-CM Code: Thalassemia minor
D56.3 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Hemolytic anemias (D55-D59)
D56.3
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceThalassemia minor
A mild form of thalassemia (a genetic blood disorder affecting hemoglobin production) where a person carries one gene for thalassemia. Most people with thalassemia minor have few or no symptoms.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Alpha thalassemia minor
- Alpha thalassemia silent carrier
- Alpha thalassemia trait
- Beta thalassemia minor
- Beta thalassemia trait
- Delta-beta thalassemia minor
- Delta-beta thalassemia trait
- Thalassemia trait NOS
Excludes 2
Official- autoimmune disease (systemic) NOS (M35.9)Inherited from D50-D89
- certain conditions originating in the perinatal period (P00-P96)Inherited from D50-D89
- complications of pregnancy, childbirth and the puerperium (O00-O9A)Inherited from D50-D89
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Inherited from D50-D89
- endocrine, nutritional and metabolic diseases (E00-E88)Inherited from D50-D89
- human immunodeficiency virus [HIV] disease (B20)Inherited from D50-D89
- injury, poisoning and certain other consequences of external causes (S00-T88)Inherited from D50-D89
- neoplasms (C00-D49)Inherited from D50-D89
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)Inherited from D50-D89
Related Codes
Includes
OfficialNo Includes notes are included in this display for D56.3. Check the code and parent instructions in the Code Book.
Excludes 1
Official- alpha thalassemia (D56.0)
- beta thalassemia (D56.1)
- delta-beta thalassemia (D56.2)
- hemoglobin E-beta thalassemia (D56.5)
- sickle-cell trait (D57.3)
- sickle-cell thalassemia (D57.4-)Inherited from D56
Code First
OfficialNo Code First sequencing instructions are included in this display for D56.3. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for D56.3. Check the code and parent instructions in the Code Book.
Code Also
OfficialNo Code Also instructions are included in this display for D56.3. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is D56.3 an HCC code?
No. D56.3 is a billable ICD-10-CM code with no mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models.
- Code
- D56.3
- Description
- Thalassemia minor
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
D56.3 is the ICD-10-CM diagnosis code for thalassemia minor. A mild form of thalassemia (a genetic blood disorder affecting hemoglobin production) where a person carries one gene for thalassemia. Most people with thalassemia minor have few or no symptoms. D56.3 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering hemolytic anemias (d55-d59).
D56.3 is a billable ICD-10-CM code, but the current payload does not show a mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.
Thalassemia minor is often asymptomatic; document any clinical manifestations if present.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D56.3 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Thalassemia minor is often asymptomatic; document any clinical manifestations if present
- •Distinguish from thalassemia major (D56.1) and thalassemia intermedia, which are more severe