D55.8

HCC Category Mapping

What This Code Means

A type of anemia caused by various enzyme disorders not specifically classified elsewhere. These enzyme deficiencies affect red blood cell function and survival.

Coding Tips

• •Use this code for enzyme-related anemias that don't fit into more specific categories
• •Document the specific enzyme disorder in the medical record even if using this catch-all code

Clinical Significance

This code captures hemolytic anemias resulting from enzyme disorders that do not fit into the more specific subcategories of glycolytic, glutathione, or nucleotide metabolism defects. These may include disorders of the hexose monophosphate shunt (other than Glucose-6-phosphate dehydrogenase deficiency) or other rare enzymopathies affecting red blood cell viability. While individually rare, they collectively represent important causes of chronic hemolysis that require ongoing clinical management.

Documentation Requirements

• ✓Documentation should describe the enzyme disorder as specifically as possible, including any enzyme assay results, genetic testing, or pathologic findings.
• ✓Record hemolysis markers, hemoglobin levels, transfusion history, and complications such as cholelithiasis or iron overload.
• ✓The provider should document why a more specific D55 subcategory code does not apply.

Commonly Confused Codes